| 刘艳 李海涛 冷静 朱国峰 文进.左旋多巴治疗帕金森病时测定血同型半胱氨酸水平的临床意义[J].,2015,15(12):2310-2312 |
| 左旋多巴治疗帕金森病时测定血同型半胱氨酸水平的临床意义 |
| The Clinical Significance of Blood Homocysteine Levels Measurement inLevodopa Treatment of Parkinson's Disease |
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| DOI： |
| 中文关键词: 左旋多巴 PD 血同型半胱氨酸 临床意义 |
| 英文关键词: Levodopa PD Blood homocysteine Clinical significance |
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| 中文摘要: |
| 目的：探讨左旋多巴治疗帕金森病（PD）时测定血同型半胱氨酸水平的临床意义。方法：收集我院内科2012 年3 月到2014
年3 月住院和门诊的PD 患者50 例（病例组)，选取健康体检者50 例作为对照组，比较两组同型半胱氨酸、叶酸以及维生素B12
差异以及同型半胱氨酸与叶酸、维生素B12 和左旋多巴剂量和PD 患者评分(UPDRS 评分)相关性。结果：病例组血浆同型半胱氨
酸水平显著高于对照组、差异具有的统计学意义（P<0.05），叶酸以及维生素B12 低于对照组，两组之间的差异具有统计学意义
（P<0.05）；按照血浆同型半胱氨酸剂量将病例组分为两个亚组，高剂量组（≥ 14 滋mol/L）和低剂量组(<14 滋mol/L)，两亚组叶酸、维
生素B12、左旋多巴剂量和UPDRS评分之间差异均无统计学意义（P>0.05）；相关性分析发现，同型半胱氨酸与叶酸、维生素B12
以及UPDRS 评分呈负相关（r= -0.545，-0.337，-0.233，P=0.001，0.009，0.013），与左旋多巴剂量呈正相关（r=0.518，P=0.001）。结论：
左旋多巴治疗PD 可使血同型半胱氨酸水平升高并降低叶酸、维生素B12 的含量，临床上应加强叶酸、维生素B12 等营养支持治
疗。 |
| 英文摘要: |
| Objective:To investigate the clinical significance of blood Homocysteine levels measured in process of Levodopa
Treatment of Parkinson's disease (PD).Methods:50 cases of PD patients from inpatient and outpatient in our hospital department of
Internal Medicine from March 2012 to March 2014 (the case group) were studied, and 50 cases of healthy were selected as control;
Homocysteine, folic acid and vitamin B12 levels between the two groups were compared and correlation between homocysteine , folic
acid,vitamin B12, levodopa dose and PD patients score (UPDRS score) were analyzed.Results:The plasma homocysteine of the case
group was significantly higher than that of the control group (P<0.05), folic acid and vitamin B12 levels were lower than those of the
control group, the difference between the two groups were statistically significant (P<0.05); The case group were divided into two
subgroups according to plasma homocysteine levels, the high-level group(≥ 14 umol/L) and low-level groups(<14 umol/L), there was on
difference in levodopa dose, folic acid and vitamin B12 and UPDRS score between the two subgroups, (P>0.05). Correlation analysis
showed a negative correlation between homocysteine and folic acid, vitamin B12 and UPDRS score (r=-0.545, -0.337, =-0.233, P=0.001,
0.009, 0.013), and a positive correlation with levodopa dose (r=0.518, P=0.001).Conclusion:Levodopa could elevate blood levels of
homocysteine, and reduce the amount of folic acid, vitamin B12 in treatment of PD, so it is necessary to enhance the folic acid, vitamin B12
and other nutritional support clinically. |
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