| 苏丽萍 袁杰 牛玉梅 王春宇 张磊 徐晓雅 孙璐璐.不同剂量的多乐氟对学龄前儿童尿氟浓度的影响[J].,2015,15(12):2293-2298 |
| 不同剂量的多乐氟对学龄前儿童尿氟浓度的影响 |
| Effects of Different Doses of Duraphat on Urinary Fluoride Concentrations ofPreschoolers |
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| DOI： |
| 中文关键词: 局部涂氟 尿氟 学龄前儿童 |
| 英文关键词: Topical fluoridization Urinary fluoride Pre-school children |
| 基金项目:卫生厅卫生行业科研专项2011-2013 年度项目(201002017) |
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| 中文摘要: |
| 目的：观察儿童使用不同剂量的多乐氟氟化钠护齿剂(Duraphat)对其尿氟浓度的影响，为Duraphat 应用于群防群治提供理论
依据。方法：采用氟离子选择电极法，将53 名3～4 岁儿童按班别分成三组，分别使用0.2 mL 及0.05 mL Duraphat涂布儿童牙齿，
检测涂氟前和涂氟后1、2、3 d的尿氟浓度，并进行组内和组间比较。结果：各组使用Duraphat后尿氟浓度逐渐增加，涂氟后2 h开
始与涂氟前比较差异均有统计学意义(P<0.05)，涂氟后3~4 h尿氟浓度达到高峰，至21 h后与涂氟前比较差异无统计学意义(P>0.
05)；3岁0.2 mL 组与0.05 mL 组在涂氟后2~4 h的尿氟浓度比较差异有显著性(P<0.05)，其他时间比较均无显著性差异(P>0.05)；
0.05 mL3 岁组与4 岁组比较尿氟浓度无明显差别(P>0.05)；3 岁初次用氟组和4 岁多次用氟组涂氟前尿氟无显著差异(P>0.05)。结
论：儿童口腔局部用氟对其尿氟浓度有影响，随局部用氟剂量的增加而增加；年龄对儿童尿氟浓度无明显影响；Duraphat在体内无
远期氟蓄积，在一定剂量内使用Duraphat可起到较好的防龋效果。 |
| 英文摘要: |
| Objective:To observe the impact of topical fluoridization with different doses of Duraphat on urinary fluoride levels of
preschoolers, and provide theoretical basis for the application of topical fluoridization with Duraphat on mass prevention and treatment.Methods:53 children aged 3 and 4 years old were divided into 3 groups, 0.2 mL and 0.05 mL duraphat were varnished on their teeth
respectively. The urinary fluoride concentration was accessed every day until the third day before and after varnishing. Fluoride
concentration was determined with a potentiometric method using an ion selective electrode, comparisons were made within groups and
among the groups.Results:The urinary fluoride levels gradually increased after using duraphat in different groups. Compared with the
baseline, there were significant differences in the urinary fluoride level 2 h after topical fluoridization with Duraphat (P<0.05), which
reached peak 3 to 4 h after topical fluoridization with Duraphat, no statistic difference was found 21 h after topical fluoridization with
Duraphat(P>0.05). The urinary fluoride levels of the groups aged 3 receiving 0.2 mL with 0.05 mL duraphat had significant differences 2
to 4 h after topical fluoridization with Duraphat(P<0.05), but no significant difference was observed at other time points(P>0.05). There
was also no obvious significance in the urinary fluoride levels among the groups aged 3 and 4 years old receiving 0.05 mL duraphat(P>0.
05), the 3-years old used duraphat once while the 4-year old used several times (P>0.05).Conclusion:Topial application of duraphat
influenced the urinary fluoride level of children in a dose dependent manner. The age of children had no influence on the urinary fluoride.
There was no fluoride retention in the body in the long term, topical fluoridization with certain dosage of Duraphat made the benefit on
the caries prevention. |
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