| 刘涛 张琼 季萍 张朝霞.2013 年新疆17 家三级医院细菌耐药性监测分析[J].,2015,15(12):2266-2272 |
| 2013 年新疆17 家三级医院细菌耐药性监测分析 |
| Monitoring and Analysis of Bacterial Resistance of 17 Tertiary Hospitals inYear 2013 in Xinjiang in China |
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| DOI： |
| 中文关键词: 细菌 耐药监测 抗生素 新疆 |
| 英文关键词: Bacteria Drug resistance monitoring Antibiotics Xinjiang |
| 基金项目:国家自然科学基金项目(81460323)；新疆医科大学第一附属医院基金项目(2013SKZD02) |
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| 中文摘要: |
| 目的：了解新疆地区17 家三级医院2013 年临床分离细菌的分布特征及对抗生素的耐药性。方法：采用最小抑菌浓度法
（MIC）和纸片扩散法（K-B）对细菌进行药物敏感试验。结果：临床共分离出细菌44022 株，其中革兰阳性菌占30.2 %，革兰阴性菌
占69.8 %。①大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌产ESBLs 菌株检出率分别为66.2 %、48.0 %和52.0 %。②鲍曼不动杆菌
和铜绿假单胞菌对亚胺培南和美洛培南的耐药率分别为51.8 %、30.4 %和37.6 %、22.9 %。③耐甲氧西林金黄色葡萄球菌
（MRSA）和耐甲氧西林凝固酶阴性葡萄球菌（MRSCN）的检出率分别为27.7 %和79.8 %。④14 岁以下儿童肺炎链球菌对青霉素
的耐药率（4.2 %）高于成人（2.1 %）。泛耐药菌株（XDR）中，鲍曼不动杆菌381 株（9.6 %），铜绿假单胞菌57 株（1.7 %），大肠埃希菌
6 株（0.1 %），肺炎克雷伯菌16 株（0.3 %）。结论：通过对细菌耐药数据分析情况来看，细菌耐药情况普遍存在，对于耐药克隆株的
传播，应加以关注；此外，应加强细菌耐药监测，合理使用抗生素。 |
| 英文摘要: |
| Objective:To investigate the distribution and antibiotic resistance of clinical bacteria isolated from17 tertiary hospitals
in year 2013 in Xinjiang in China.Methods:Antimicobial susceptibility test was carried out for the clinical isolation according to an
agreed protocol using Minimum inhibitory concentration (MIC) and Kirby-Bauer (K-B) method. And the results were analyzed.Results:44,022 clinical bacteria were isolated, Gram-positive bacteria and Gram-negative bacteria accounted for 13,287 (30.2 %) and 30,735
(69.8 %). The detection rate of extended-spectrum beta-lactamase (ESBLs) in , and
was 66.2 %, 48.0 %and 52.0 %, respectively. The resistance rates of and to
Imipenem and Meropenem were 51.8 %, 30.4 % and 37.6 %, 22.9 %, respectively. The detection rate of methicillin-resistant strains in
(MRSA) and (MRSCN) was 27.7%and 79.8 %, respectively. The detection
rate of of children under the age of 14 to PenicillinG (4.2 %) was higher than adults over the age of 15. The
Extremely-drug Resistant (XDR) of , , and were
381 (9.6 %), 57 (1.7 %), 6 (0.1 %) and 16 (0.3 %), respectively.Conclusion:From the distribution of clinical isolation of bacteria and
antibiotic resistance analysis, bacterial resistance is widespread, antimicrobial resistance monitoring should be strengthened, and the
rational use of antibiotics should be improved. |
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