| 刘玲华 刘正 杨明 李伟军 付小玻 张晓梅.DNA损伤与眼病相关性的研究进展[J].,2015,15(11):2177-2180 |
| DNA损伤与眼病相关性的研究进展 |
| Research Progress in Eye Diseases Associated with DNA Damage |
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| DOI： |
| 中文关键词: DNA 损伤 修复 晶状体上皮细胞 视网膜色素上皮细胞 |
| 英文关键词: DNA damage Repair Lens epithelial cells Retinal pigment epithelial cells |
| 基金项目:黑龙江省教育厅科学技术研究项目（11531179） |
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| 中文摘要: |
| DNA损伤是复制过程中发生的DNA核苷酸序列永久性改变，并导致遗传特征改变的现象。对DNA损伤与修复的研究是
现代分子生物学研究的热点之一。目前，DNA 损伤对眼组织细胞凋亡、基因改变、细胞活性的影响已成为眼科疾病研究的热点。在
年龄相关性白内障、老年性黄斑病变等眼科疾病的病因研究中证实氧化应激是其主要致病因素，当机体遭受有害刺激导致氧化
应激时，机体、组织、细胞受到一系列损伤，而DNA 的损伤对氧化应激最为敏感。本文就DNA 损伤及其与晶状体上皮细胞及视网
膜色素上皮细胞相关性的研究进展作一综述，为眼科疾病的研究以及防治提供新的方法及思路。 |
| 英文摘要: |
| DNA damage is a permanent change which occur during replication of DNA nucleotide sequence and it can result in
genetic characteristics changes. The study of DNA damage and repair is one of the hot topics in the study of modem molecular biology.
Currently, DNA damage has become a ophthalmic diseases hot research in eye tissue cells apoptosis, genetically modified, cell activity.
In senile cataract, age-related macular degeneration and other eye disease etiology study confirmed that oxidative stress is the main
pathogenic factors. However, when the body is stimulated by harmful factors which cause the oxidative stress, the body, tissues and cells
will be injured, And the DNA damage of oxidative stress are the most sensitive. In this paper, DNA damage and its correlation with lens
epithelial cells and retinal pigment epithelial cells research progress are reviewed, In order to provide new method and thought for the
research and prevention of eye disease. |
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