| 申骏龙 雷光焰 吕卫东.通过模拟胚胎微环境逆转肿瘤的研究进展[J].,2015,15(11):2154-2156 |
| 通过模拟胚胎微环境逆转肿瘤的研究进展 |
| Progress in Reversal of Tumor byMimicking Embryonic Microenvironment |
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| DOI： |
| 中文关键词: 肿瘤 胚胎干细胞 肿瘤干细胞 微环境 组织工程 |
| 英文关键词: Tumor Embryonic stemcell Cancer stemcell Microenvironment Tissue engineering |
| 基金项目:国家自然科学基金项目（31100686） |
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| 中文摘要: |
| 肿瘤的发生和发展源于一小部分具有自我更新能力的肿瘤干细胞。胚胎干细胞也具有自我更新和多向分化的特性。胚胎干
细胞特异的基质微环境能够提供干细胞正常生长的调控分子，在细胞不断更新的情况下，使增殖和分化达到平衡。受胚胎干细胞
调节的基质或胚胎微环境作用于肿瘤细胞，可以使肿瘤细胞获得更多的分化表型，显著降低其恶性程度，抑制肿瘤细胞的侵袭行
为。进一步的分子机制研究发现，在肿瘤细胞中高表达的Nodal 蛋白会抑制肿瘤细胞分化，而胚胎干细胞分泌的糖基化Lefty蛋
白可以负反馈调节Nodal蛋白的作用，从而降低肿瘤细胞的恶性程度。利用组织工程来模拟胚胎干细胞微环境，保留Lefty蛋白，
从而逆转肿瘤的方法具有广阔的前景。 |
| 英文摘要: |
| The neoplasm is derived from a little part of cancer stem cells with unregulated self-renewal capability. Embryonic
stem cells also have the characteristics of self-renewal and multi-directional differentiation. The specific stromal microenvironment of
embryonic stemcells can provide stemcells with regulation molecules of normal growth to keep the balance of proliferation and differentiation.
The extracellular matrix or embryonic microenvironment regulated by embryonic stem cells can provide tumor cells with more
differentiated phenotype. The malignant and invasive behaviors of tumor cells were inhibited. The molecular mechanisms of further study
present that Nodal protein, which is high-level expressed in tumor cells, can inhibit tumor cell differentiation. The glycosylation Lefty
protein secreted by embryonic stem cells can adjust the action of Nodal protein with negative feedback and reduce the malignant degree
of tumor cells. It is of a good application prospect to use tissue engineering method to mimic the embryonic stem cell microenvi- ronment
to reverse the progress of the tumors. |
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