| 殷香宇 杨珊珊 申龙健 王建秀.吉兰—巴雷综合征与空肠弯曲菌感染[J].,2015,15(9):1788-1790 |
| 吉兰—巴雷综合征与空肠弯曲菌感染 |
| Guillain - Barre Syndrome and Campylobacter Jejuni Infection |
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| DOI： |
| 中文关键词: 吉兰—巴雷综合征 空肠弯曲菌 感染 自身免疫疾病 |
| 英文关键词: Guillain - Barre syndrome Infection Autoimmune diseases |
| 基金项目:哈尔滨医科大学伍连德青年科学基金项目（WLD-QN1113）；黑龙江省博士后基金项目(LBH-Z12160) |
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| 中文摘要: |
| 吉兰- 巴雷综合征是自身免疫介导的周围神经病，主要的病理改变是周围神经组织小血管淋巴细胞、巨噬细胞浸润，神经纤
维脱髓鞘，严重病例可继发轴索损害。吉兰—巴雷综合征的发生是由于易感人群感染病原菌后，机体针对病原菌抗原成分产生相
应抗体，该抗体与人体神经节苷脂发生交叉免疫反应；同时在多种细胞因子的协同作用下，影响神经传导功能，最终产生不同程
度的髓鞘脱失，严重者可导致轴索变性。空肠弯曲菌是其中最常见的病原菌，本文就吉兰—巴雷综合征与空肠弯曲菌感染的关系
予以综述。 |
| 英文摘要: |
| Gillan - barre syndrome is immune-mediated peripheral neuropathy itself, whose the main pathological changes is the
peripheral nerve tissue small blood vessels lymphocytes, macrophages infiltration, and the nerve fibers demyelination, severe cases can be
secondary to the axon damage. Gillan - barre syndrome is due to the vulnerable groups of pathogenic bacteria infection and the body
produce antibodies against pathogens antigen components, the ganglioside antibodies to human body cross immune reaction.At the same
time under the synergy of many kinds of cytokines, affect nerve conduction function, resulting in different levels of myelin
depigmentation, severe cases can lead to axonal degeneration. Jejunum bending bacteria is one of the most common pathogenic bacteria,
in this paper, the gillan - the barre syndrome and relationship of jejunumbending bacteria infection were reviewed. |
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