| 赵琳琳 孙夕林 王凯 黄涛 王丹 申宝忠.脑白质疏松症弥散张量成像的探讨[J].,2015,15(9):1748-1751 |
| 脑白质疏松症弥散张量成像的探讨 |
| The Investigation of Leukoaraiosis in Diffusion Tensor Imaging |
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| DOI： |
| 中文关键词: 脑白质疏松 弥散张量成像 脑白质纤维束成像 |
| 英文关键词: Leukoaraiosis Diffusion tensor imaging Diffsion tensor tractography(DTT) |
| 基金项目:国家自然科学基金重点项目（81130028）；国家自然科学基金重大国际（地区）合作项目（31210103913）；
黑龙江省科技攻关重大项目（GA12C302） |
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| 中文摘要: |
| 脑白质疏松症发病率逐渐增高，其相关的神经功能障碍严重影响生活质量，因此早期发现LA 患者存在的隐匿性损伤对早
期治疗及预防有重要临床意义。LA 的病理生理学特点为血管内皮细胞的受损引起血管通透性的改变，从而使周围组织的弥散程
度发生改变，细胞外水分子运动对信号的改变起主导作用。DTI 是目前检测脑白质唯一的无创性方法,可从量和方向上反映成像
的体素内水分子扩散的变化，可以测量组织中扩散的各向异性。DTI较传统的MR 能更好的反应神经系统白质的超微结构的改
变，为影像学与其病理生理的相关性研究提供新的方法。目前对脑白质疏松的研究主要集中在与神经功能相关区域DTI量化指
标的改变，因此本文对脑白质疏松的DTI技术的应用及发展趋势进行综述。 |
| 英文摘要: |
| The leukoaraiosis incidence is increasing, related neurological dysfunction seriously affect the quality of life. Early
found the occult injury of LA is very important to clinical significance for early treatment and prevention. The pathophysiology of LA is
vascular endothelial cell damage caused by vascular permeability changes, Thereby the degree of dispersion of the surrounding tissue
changed. Water molecular motion in cellular played a leading role in signal change. DTI is the only noninvasive method to detect brain
white matter microstructure, which can be reflected from the amount and direction of changes in water diffusion imaging voxel and can
be measured diffusion anisotropy in the organization. Compared with conventional MR, DTI reactived the nervous system white matter
ultrastructural changes. Provide a new method for imaging which related to its pathophysiology. The research of leukoaraiosis mainly
concentrated in the DTI quantitative indicators of changes in nerve function related regional. In this paper, the white matter of brain DTI
technological application and development tendency were reviewed. |
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