| 季伟俐 贺振秋 马雪松 韩宝庆 戚思华.不同效应室浓度舒芬太尼复合丙泊酚对 Narcotrend 的影响[J].,2015,15(7):1290-1293 |
| 不同效应室浓度舒芬太尼复合丙泊酚对 Narcotrend 的影响 |
| Influence of Different Effect Compartment Concentration of SufentanilCombined with Propofol on Narcotrend |
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| DOI： |
| 中文关键词: 舒芬太尼 靶控输注 效应室浓度 丙泊酚 |
| 英文关键词: Sufentanil Targeted controlled injection Effect compartment concentration Propofol |
| 基金项目:黑龙江省科学基金重点项目（ ZD201 017） |
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| 中文摘要: |
| 目的： 探讨靶控输注不同 效应室浓度的舒芬太尼复合丙泊酚对 Narcotrend 指数（ NI）的影响。 方法： 选择 60 例 全麻患者，年
龄 40-60 岁 ， 体重指数＜ 30 kg/m2， ASAⅠ -Ⅱ 级， 随机分为 4 组（ n=15）：舒芬太尼效应室靶控浓度 0.1 ng/mL(A 组)、 0.2 ng/mL(B
组)、 0.3 ng/mL(C 组)、 0.4 ng/mL(D 组)；各组舒芬太尼达效应室靶浓度 5 min 后给予丙泊酚 1 mg/kg。 记录实验过程中的血压、心
率、血氧饱和度及 NI。 所有患者在实验结束后，均调整至适宜的麻醉深度， 给与 阿曲库胺，进行气管插管。 结果： 靶控输注舒芬太尼
使各组的 NI 有不同 程度的降低，随着靶控浓度的增加， 降低幅度增大； 单纯靶控输注舒芬太尼时， 其效应室浓度与 NI 呈负 相关，
相关系数为 -0.456。 结论： 舒芬太尼能降低 NI，舒芬太尼效应室浓度与 NI 呈负 相关。 而舒芬太尼效应室浓度 0.4 ng/mL 复合丙泊
酚后， NI 反而呈短暂的上升，随后下降的现象。 |
| 英文摘要: |
| Objective:To investigate the effects of different effect compartment of sufentanil combined with propofol by target
controlled infusion on Narcotrend index.Methods:60 patients, aged 40~60, weight index<30 kg/m2, ASAⅠ -Ⅱ undergoing general anesthesia were randomly divided into 4 groups (n=15): sufentanil effect compartment concentration 0.1 ng/mL (group A), 0.2 ng/mL(group
B), 0.3 ngmL (group C), and 0.4 ng/mL (group D). The propofol of 1 .0 mg/kg was administered after 5 min when the concentration of
sufentanil reached the effect compartment concentration. The parameters of BP, HR, SpO2 and Narcotrend index(NI) were recorded during proceeding of experiments. After experiments, all of patients were adjusted to appropriate anesthesia depth, then the muscle relaxants
were administered and the tracheal intubations were done.Results:The NI decreased in varying degree with target injection of sufentanil,
accompanied with the increase of target concentration, the trend of decrease is more obvious. During target-controlled infusion of sufentanil as sole, there was a negative correlation between the effect compartment concentration and NI, and the correlation index is -0.456.
After 1 min of injecting propofol, the NI of Group D ascended initially, with statistical significance in comparison among groups (P<0.
05), then the NI1 was decreased with the time.Conclusion:Sufentanil can decrease the NI, and the correlation between the effect compartment concentration and NI is negative, while sufentanil of 0.4 ng/mL effect compartment concentration combined with propofol
caused the phenomenon that the NI raised temporarily, whereafter decreased. |
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