| 于洪文 麦 威 宋春雨 魏天犁 包俊杰 曲国蕃.骨肉瘤相关基因的研究[J].,2015,15(5):966-968 |
| 骨肉瘤相关基因的研究 |
| Study on Genes Related in Osteosarcoma |
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| DOI： |
| 中文关键词: 骨肉 瘤 癌基因 抑癌基因 |
| 英文关键词: Osteosarcoma Oncogene Anti-oncogene |
| 基金项目: |
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| 中文摘要: |
| 骨肉 瘤为最常见的恶性骨肿瘤，多 发于 10-25 岁青少年， 恶性程度高，复发率，转移率， 死亡率高。 虽 然骨肉 瘤化学治疗的开
展明显提高了 骨肉 瘤患者的生存率， 但效果并不很令人满意。 近些年来，随着分子生物学、分子遗传学的发展， 人们已经越来越多
的认识到， 骨肉 瘤的发生、发展及预后往往涉及多 个基因 的改变，包括致癌基因 的表达及活化，抑癌基因 的丢失及失活。 本文通过
查询近年大量国内外关于骨肉 瘤癌基因 方面的文献， 分析与 骨肉 瘤发生、发展及预后密切相关的致癌基因 及抑癌基因 。 希望通过
对这些基因 深入的探讨，为骨肉 瘤的治疗 寻找新的方向及新的潜在的治疗新靶点奠定理论基础。 |
| 英文摘要: |
| Osteosarcoma is the most common malignant bone tumour, with a peak incidence in children and young adolescents
aged 10-25 years, osteosarcoma has a high malignant level, in mortality, local recurrence rate and the distant metastasis rate were higher.
Though intensifying or modifying chemotherapy improved survival rate for patients with osteosarcoma, but the effect was unsatisfactory.
In recent years, with the development of molecular biology and molecular genetics, more and more people have come to realize that the
expression and regulation of certain genes may be involved in occurrence, development and prognosis of osteosarcoma, which include
activation and expressions of oncogene, deletion and inactivationof anti-oncogene. This paper discusses oncogene and anti-oncogene
with occurrence, development and prognosis of osteosarcoma, based on a large number of domestic and foreign documents and papers
about osteosarcoma gene of analysis. It was from the study of these that offers new directions to find out a new target in the future
treatments of osteosarcoma. |
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