| 高丽园 张丽琼 刘子睿 周媛 曹 磊.Muller 细胞与视网膜病变[J].,2015,15(5):963-965 |
| Muller 细胞与视网膜病变 |
| Muller Cells and Retinopathy |
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| DOI： |
| 中文关键词: Muller 细胞 视网 膜病变 |
| 英文关键词: Muller cells Retinopathy |
| 基金项目:黑龙江省自然科学基金项目（ D200949）；哈尔滨市科技局资助项目（ 2007RFQXS090）；
黑龙江省教育厅科学技术研究项目（ 1 1541219）；黑龙江省卫生厅科研项目（ 2007-222） |
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| 中文摘要: |
| 视网 膜是一薄而半透明 的、具有多 层结构的神经组织， 位于眼球后 2/3 部的内 侧面。 向前延伸达睫状体,止于不规则 边界。
Muller 细胞是脊椎动物视网 膜内 最主要的神经胶质细胞，它贯穿整个视网 膜。 Muller 细胞对于维持神经元的完整性、代谢、内 环境
稳态以及信号转导等均具有重要的作用 。在视网 膜病变时， Muller 细胞参与 整个过程， 并且在视网 膜的各种疾病中都发现伴有
Muller 细胞的神经胶质增生反应。 Muller 细胞同时也调控视网 膜病变的整个过程。 Muller 细胞膜上的神经递质受体、谷氨酸受体、
门 控电压通道、所合成分泌的营养因 子及自 的身增殖分化都发生改变。 近年来人们对 Muller 细胞的认识越来越多 ， 研究的方向也
从细胞的微观结构、主要功能转变成 Muller 细胞对不同 视网 膜病变过程的参与调控。 本文对视网 膜 Muller 细胞的形态和生理功
能，病理状况下 Muller 细胞发生的改变作一综述。 |
| 英文摘要: |
| The retina is a thin, semitransparent, multilayered sheet of neural tissue that lines the inner aspect of the posterior
two-thirds of the wall of the globe. It extends almost as far anteriorly as the ciliary boby, ending at that point in a ragged edge. Muller
cells are the main glial cells in vertebrate animal retina, it runs through the whole retina. Muller cells play an important role in the maintainence of the integrity of the neurons, metabolism, homeostasis and signal transduction. In retinopathy, Muller cells participate in the
whole process, and Muller glial cells proliferation response are found in all kinds of retinal diseases. Muller cells also regulate the whole
process of retinopathy. The neurotransmitter receptors, glutamic acid receptor, the voltage channel gating, the synthesis of neurotrophic
factor secretion and their proliferation and differentiation of Muller cell membrane all have changed. In recent years, people have shown
more and more understanding of Muller cells. The direction of the research has also changed from the microscopic structure of cells and
the main functions into the regulation of different processes of retinopathy. In this review, the morphology and physiological functions of
retinal Muller cells, and Muller cell changes in the pathological conditions were summarized. |
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