| 鲍雷 史明 姚媛菲 李钰 李晖.Toll样受体与肿瘤免疫[J].,2015,15(4):771-773 |
| Toll样受体与肿瘤免疫 |
| Toll-like Receptors and Tumor Immunology |
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| DOI： |
| 中文关键词: Toll样受体 肿瘤免疫 免疫抑瘤 免疫逃逸 |
| 英文关键词: Toll-like receptors Tumor immunology Tumor suppression Immune evasion |
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| 中文摘要: |
| Toll样受体(Toll-like receptor)是天然免疫系统中最重要的模式识别受体，在病原体感染过程中对入侵病原体的识别，激活
免疫应答起重要作用。近年发现Toll样受体在多种肿瘤的发生过程中起重要的调控作用。Toll 样受体在肿瘤细胞中具有表达，并
且Toll 样受体信号诱导的促炎症反应是肿瘤发生的必要条件，但是有些Toll 样受体的配体仍然表现出极强的抗肿瘤活性，目前，
Toll样受体在肿瘤免疫中的机制研究已经成为Toll 样受体作为药物靶点的临床应用的关键。本文对Toll样受体在肿瘤免疫中的
机制进行综述。 |
| 英文摘要: |
| Toll-like receptors are the most important pattern recognition receptors in innate immunity, which play a key role in
activating immune response via recognizing pathogens during infection. Recently, it has been found that Toll-like receptors play a regulatory
role in the development of various cancers. Evidences show that Toll-like receptors are expressed in cancer cells, and proinflammatory
response induced by Toll-like receptor signaling is necessary for cancer development. However, certain ligands for Toll-like receptors
show strong anti-tumor activity. Nowadays, the mechanism of Toll-like receptors in tumor immunology has become a critical factor
in targeting on Toll-like receptors for clinical application. In this article, we reviewed recently reported studies on the mechanism of
Toll-like receptors in tumor immunology. |
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