| 姜成功 苏颖 曲艺欣 陈敬丽 刘洪涛 王峰.青光眼术后抗滤过泡瘢痕化药物进展[J].,2015,15(4):765-767 |
| 青光眼术后抗滤过泡瘢痕化药物进展 |
| Progress of The Anti-scarring Drugs in Bleb after Trabeculectomy |
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| DOI： |
| 中文关键词: 青光眼 小梁切除术 成纤维细胞 细胞增殖 |
| 英文关键词: Glaucoma Trabeculectomy Fibroblast Proliferation |
| 基金项目:国家自然科学基金项目（81100659） |
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| 中文摘要: |
| 青光眼是全世界排名第二位的导致视力下降或丧失的眼病，对视力的损害严重且不可逆，使青光眼的早期诊断和治疗显得
尤为重要。目前，青光眼滤过性手术仍是降低患者眼内压最有效的治疗方法，但经滤过减压术后，青光眼患者滤过泡成纤维细胞
的增殖和胶原的沉积，会导致滤过泡功能不同程度的减退，减少了滤过性手术的成功率。为减轻这种不必要的瘢痕愈合，一些抗
瘢痕形成药物被越来越多应用于青光眼滤过手术的实验与临床研究中。本文对目前这些主要的青光眼滤过性手术后抗滤过泡瘢
痕的药物的作用机制及临床治疗效果进行综述。 |
| 英文摘要: |
| Glaucoma is the second eye diseases in the world that leads to vision loss or loss of serious irreversible damage to vision.
It is particularly important to make early diagnosis and treatment of glaucoma. Currently, glaucoma filtration surgery which reduces
the patient's intraocular pressure(IOP) is the most effective treatment method. But excessive fibroblastic proliferation, an increase in collagen
deposition and the formation of scar result in the bleb dysfunction after trabeculectomy, which leads to decrease success rate of filtration
surgery. To alleviate this unnecessary scar healing, anti-scarring drugs are more and more frequently used in glaucoma filtration
surgeryinexperimental andclinical studies. Therefore, thisreviewfocusesonthemainlyanti-scarringdrugs after glaucoma filtrationsurgery. |
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