| 王志刚 黄宁 李冰 张建.地塞米松联合昂丹司琼对胸腔镜术后病人静脉自控镇痛PONV的影响[J].,2015,15(4):689-691 |
| 地塞米松联合昂丹司琼对胸腔镜术后病人静脉自控镇痛PONV的影响 |
| The Effect of Combining Dexamethasone with Ondansetron for Nausea andVomiting Associated with Sufentanyl-based Intravenous Patient-controlledAnalgesia |
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| DOI： |
| 中文关键词: 地塞米松 昂丹司琼 术后恶心呕吐 病人自控镇痛 |
| 英文关键词: Dexamethasone Ondansetron Postoperative nausea and vomiting Patient-controlledanalgesia |
| 基金项目:黑龙江省省青年基金项目（QC08C45） |
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| 中文摘要: |
| 目的：观察地塞米松联合昂丹司琼对胸腔镜术后病人自控静脉镇痛（PCIA）相关恶心呕吐的防治效果。方法：120 例ASAⅠ
～Ⅱ接受胸腔镜手术的患者，随机分为两组：地塞米松与昂丹司琼联合组（OD组）和昂丹司琼组（O组）。OD组患者在诱导时给予
10 mg地塞米松，O 组给予等量生理盐水，在手术结束前10 分钟时，患者均给予静脉注射8 mg 昂丹司琼，术后均行病人自控静脉
镇痛（PCIA：生理盐水将2 滋g/kg 舒芬太尼和8 mg昂丹司琼稀释到100 mL）。观察术后48 小时内的恶心呕吐的发生率及严重程
度。结果：在术后恶心呕吐整体发生率上OD 组（53.3%）与O 组（60%），差异无统计学意义（P>0.05），但在重度PONV 发生率上
OD 组（10%）要显著低于O 组（26.7%），差异有统计学意义（P<0.05）。结论：地塞米松联合昂丹司琼能有效地降低胸腔镜手术后以
舒芬太尼为主的病人自控静脉镇痛所致严重恶心呕吐的发生率。 |
| 英文摘要: |
| Objective:We investigated whether combined dexamethasone and ondansetron is more effective than ondansetron
alone in preventing postoperative nausea vomiting in patients with patient-controlled analgesia.Methods:One hundred and twenty patients
ASAⅠtoⅡwho underwent video-assisted thoracoscopic surgery were assigned to either an ondansetron group (groupO) or a dexamethasoneand
ondansetron group (group OD). In all patients, ondansetron 8mg was administered at the end of surgery and 8 mg was
added to the patient-controlled analgesia solution. The dexamehthasone and ondnsetron group received dexamethasone 10 mg at the induction
of anaesthesia.Results:The overall incidence of nausea and vomiting during the first 48h postoperatively did not differ between
groups (60%) vs (53.3%) in the ondansetron group and dexamethasone and ondansetron goup). The incidence of severe nausea and vomiting
was higher in the ondansetron group than in the dexamethasone and ondansetron group (26.7%) vs (10%).Conclusion:Combined
dexamethasone and ondansetron is more effective in reducing sevsre nausea and vomiting than ondansetron alone in patients receiving
sufentanyl-based intravenous paient-controlled analgesia. |
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