| 周芳辉 郭晓钟 李宏宇 崔忠敏 张宁宁 姚辉 张永国.连续肾脏替代疗法治疗重症急性胰腺炎时机的探讨[J].,2015,15(4):672-675 |
| 连续肾脏替代疗法治疗重症急性胰腺炎时机的探讨 |
| Research on the Application Time of Continuous Renal ReplacementTherapy for Severe Acute Pancreatitis |
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| DOI： |
| 中文关键词: 连续肾脏替代治疗 重症急性胰腺炎 早期 时机 |
| 英文关键词: Continuous renal replacement therapy Severe acute pancreatitis Early stage Opportunity |
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| 中文摘要: |
| 目的：探讨连续肾脏替代疗法(CRRT)治疗重症急性胰腺炎的最佳时机。方法：选取我院收治的30 例重症急性胰腺炎(SAP)
患者为研究对象，按发病后行CRRT 的时间分将患者随机为A、B 两组，A 组发病后72小时内治疗，B 组发病后72 小时后治疗，
分析和比较两组治疗后的临床转归及生命体征变化、APACHE Ⅱ评分变化急性生理与慢性健康状况、住院费用、平均住院时间。
结果：经CRRT 治疗后，A 组死亡率(14.3%)低于B 组(43.7%)，差异有统计学意义(P<0.05)；A、B 两组治疗后体温、心率、呼吸、平均
动脉压平稳，A 组优于B 组，差异有统计学意义(P<0.05)；A 组的平均住院时间(15.7± 8.9)d、住院费用(107000± 65000)万元均明显
优于B 组，差异有统计学意义(P＜0.05)；两组患者治疗后APACHE Ⅱ评分均明显优于治疗前，治疗后A 组APACHE Ⅱ评分明显
优于B 组，差异显著有统计学意义（P＜ 0.05)。结论：早期行CRRT 能明显改善重症急性胰腺炎患者的疗效和预后，最佳治疗时机
可能为发病后72 小时内。 |
| 英文摘要: |
| Objective:To discuss the best application time of continuous renal replacement therapy for severe acute pancreatitis.Methods:30 cases of patients with severe acute pancreatitis (SAP) were selected in our hospital as the research object, according to the
onset of CRRT after time, they were divided into group A and group B. Group A was treated within 72h after onset, while Group B was
treated in the pathogenesis of 72 h. The clinical outcome and changes of invital signs, APACHE II score, hospitalization costs and average
hospitalization time were analyzed.Results:After the CRRT, the mortality rate (14.3%) of Group A was lower than that of group B
(43.7%), the difference was statistically significant (P<0.05); after the treatment, two groups of treatment, heart rate, respiratory rate and
mean arterial pressure were stable, Group A was better than that of group B, and the difference was statistically significant (P<0.05); The
average hospitaliza- tion time (15.7± 8.9) days, hospitalization costs (107000± 65000)yuan of group A were significantly better than
those in group B, with significant difference (P<0.05); the APACHE II score after the treatment of the two groups were significantly higher
than those before treat- ment, group A APACHE II score was significantly better than that in group B, the difference was significant
(P<0.05).Conclusion:Early continuous renal replacement therapy can significantly improve the curative effect and prognosis of acute
pancreatitis, and the optimal timing of treatment may be within 72 hours after onset. |
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