| 刘玠 初李佳娃 褚利娟 笔雪艳 曲海影 常越.治糜灵凝胶剂的薄层色谱鉴别研究[J].,2015,15(2):332-335 |
| 治糜灵凝胶剂的薄层色谱鉴别研究 |
| Study on the TLC Identification Method of Zhimiling Gels |
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| DOI： |
| 中文关键词: 治糜灵凝胶剂 薄层色谱 黄柏 苦参 儿茶 冰片 |
| 英文关键词: Zhimiling Gels TLC Cortex Phellodendri Sophora flavescens Acacia catechu Borneol |
| 基金项目:黑龙江省科技攻关计划项目(2005G4060-00) |
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| 中文摘要: |
| 目的：将治糜灵栓剂（《中国药典》2010 版一部）改为治糜灵凝胶剂，建立治糜灵凝胶剂的薄层色谱鉴别方法，为制定其质量
控制标准制定依据。方法：参照《中国药典》2010 版一部治糜灵栓剂项下黄柏、苦参、儿茶、冰片的薄层色谱鉴别方法，对处方中的
主要药味进行定性鉴别。黄柏鉴别中以甲苯- 乙酸乙酯-异丙醇- 水(6:3:1.5：1.5)为展开剂；苦参鉴别中以甲苯- 乙酸乙酯-甲醇
（8:3:0.5）为展开剂；儿茶鉴别中以正丁醇- 醋酸- 水（3:2:1）为展开剂；冰片鉴别中以环己烷- 三氯甲烷- 乙酸乙酯（9:1:2）为展开
剂。结果：薄层色谱上具有黄柏，苦参，儿茶，冰片的鉴别特征，且阴性对照无干扰。结论：色谱斑点清晰，专属性强；该方法操作简
便，稳定性、重现性均很好。可作为质量标准的控制依据。证明治糜灵凝胶剂研究的方法可行。 |
| 英文摘要: |
| Objective:To verify the feasibility that changing Zhimiling suppositories (published in the "Chinese
Pharmacopoeia"2010) into Zhimiling gels, and to establish TLC identification method of Zhimiling Gels, and support to set up quality
control standard for the product.Methods:In accordance with the "Chinese Pharmacopoeia"2010 A, TLC identification method of Cortex
Phellodendri, Sophora flavescens, Acacia catechu and Borneol was performed. And a qualitative identification of the main drugs in the
prescription was detected. The developer for Cortex Phellodendri was methylbenzene- ethyl acetate- so-Propyl alcohol-water (6:3:1.5：
1.5); for Sophora flavescens was methylbenzene- ethyl acetate- methyl alcohol (8:3:0.5); for Acacia catechu was butyl alcohol-
AceticAcid -water (3:2:1); for Borneol was cyclohexane- Trichloromethane- ethyl acetate (9:1:2).Results:Cortex Sophora flavescens,
Acacia catechu and Borneol could be clearly detected by TLC, while the negative control had no interference.Conclusion:TLC spots
was obvious, and the method was specific, simple, stability and with good reproducibility to be used as quality control guide line for the
Zhimiling Gels , which prove the study of Zhimiling gels is feasible. |
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