| 唐进 杨涛 熊小江 关群 刘王卫.盐酸氨基葡萄糖联合塞来昔布治疗不同程度膝关节骨性关节炎
的临床研究[J].,2015,15(2):294-297 |
| 盐酸氨基葡萄糖联合塞来昔布治疗不同程度膝关节骨性关节炎
的临床研究 |
| The Clinical Study of Glucosamine Hydrochloride Combined with Celecoxibfor Different Degrees of Knee Osteoarthriti |
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| DOI： |
| 中文关键词: 盐酸氨基葡萄糖 塞来昔布 膝关节 骨性关节炎 临床价值 |
| 英文关键词: Glucosamine hydrochloride Celecoxib Knee Osteoarthriti Clinical significance |
| 基金项目: |
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| 中文摘要: |
| 目的： 研究盐酸氨基葡萄糖联合塞来昔布治疗不同 程度膝关节骨性关节炎的临床价值。 方法： 选取 2011 年 1 月至 2014 年 2
月 已被收治的符合标准的病例共 150 例 ,按照病情轻重分为轻度（ 64 例）、中度（ 52 例）及重度（ 34 例）3 组， 各组又随机等分为 治疗
组和对照组两组，治疗组给盐酸氨基葡萄糖联合塞来昔布治疗，对照组仅给予盐酸氨基葡萄糖治疗，分别于给药第 2、 4 、 6 周以及
停药 8、 12 周 观察两组患者经两种不同的治疗 方案治疗 后患者的 Lequesne 评分有无统计学差异。 结果： 轻度： 两组停药 12 周 后
Lequesne 评分仍低于治疗 前，差异有统计学意义（ P<0.05）， 停药 12 周时治疗组低于对照组，差异有统计学意义（ P<0.05）。 中度： 用
药 2 周 、 4 周、 6 周 及停药 8 周时两组相比差异均有统计学意义 （ P<0.05）。 重度： 对照组与 治疗 组在给药 4 周 及给药 6 周时其
Lequesne 评分差异有统计学意义（ P<0.05）， 停药后均无统计学意义（ P>0.05）。 结论： 单用 盐酸氨基葡萄糖可改善轻度膝关节骨
性关节炎的临床症状， 对于中度患者联合非类固醇类抗炎药类有较好疗效，对于重度患者两种方式都无明显效果。 |
| 英文摘要: |
| Objective:To study the clinical significance of glucosamine hydrochloride combined with celecoxib in the treatment of
different degrees of knee osteoarthriti.Methods:150 cases who were in accordance with the standards in our hospital from January 2012
to February 2014 were selected and divided into the mild group, moderate group and severe group according to the severity, and each
group was further equally divided into the treatment group and the control group randomly, the treatment group was given glucosamine
hydrochloride combined with celecoxib, while the control group was given glucosamine hydrochloride. Lequesne score were recorded at
2, 4, 6 weeks after drug administration and 8 and 12 weeks after drug withdrawal, data were compared between the two groups and
among different time points.Results:In the mild group, the lequesne score of the two groups at 1 2 weeks after drug withdrawal were
lower than that before the treatment, the difference was statistically significant (P<0.05), the lequesne score in the treatment group was
lower than that in the control group in 1 2 weeks after drug withdrawal, the difference was statistically significant (P<0.05); In moderate
group, there were statistically significantly differences in the comparison of the two groups at the time of 2, 4, 6 weeks after drug
administration and 8 weeks after drug withdrawal (P<0.05); In severe group, there were statistically significantly differences in
comparison of the two groups at 4 and 6 weeks after drug administration (P<0.05), and there were no statistically significant differences
after drug withdrawal(P>0.05).Conclusion:Using pure glucosamine hydrochloride could improve the clinical symptoms in patients with
mild knee osteoarthriti, glucosamine hydrochloride combined with celecoxib has good curative effects for moderate patients, while
neither of the two treatment methods has obvious effects on severe patients. |
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