| 陈和敏 申婷 游晶 张茹意 杨波 陈思如.Th17 细胞的分化、调节及其主要细胞因子和功能[J].,2015,15(1):191-194 |
| Th17 细胞的分化、调节及其主要细胞因子和功能 |
| Differentiation, Adjustment of Th 17 and it's Main Cytokines and Function |
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| DOI： |
| 中文关键词: Th17 细胞 IL-17 IL-21 |
| 英文关键词: T help cell 17 Interleukin 17 Interleukin 21 |
| 基金项目: |
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| 中文摘要: |
| 近几年来以分泌白介素17（interleukin 17, IL-17）为特征的辅助性T细胞Th17（T help cell 17, Th17）细胞被认为是有区别于
Th1（T help cell 1, Th1）、Th2（T help cell 2, Th2）新型的细胞亚群，它的发现改变了以往人们只将Th 细胞分为Th1、Th2 的传统分
类认识。Th17 细胞参与了自身免疫疾病、肿瘤的发生及机体各种炎症的发病机制，其分泌的细胞因子在生物学功能中发挥了极其
重要的作用。同时Th17 细胞的活化需要各种转化生长因子、IL-6（interleukin 6, IL-6）、IL-23（interleukin 23, IL-23）等细胞因子的参
与，活化的Th17 细胞同时再进一步的促进各种细胞因子的分泌，以通过分泌IL-17、IL-21（interleukin 21, IL-21）、IL-22（interleukin
22, IL-22）、IL-26（interleukin 26, IL-26）、肿瘤坏死因子（tumor necrosis factor，TNF）alpha等细胞因子导致机体炎症等各种疾病的发生。 |
| 英文摘要: |
| In recent years, Th17 cell characterized by secreting IL-17 is a cell subset supposed to be different from Th1 and Th2
cells, it is found that has changed people traditional classification recognition that Th cells are only classified into Th1 and Th2. Th17 cell
are involved in the autoimmune disease, the occurrence of tumor and the pathogenesis of various inflammation, that secreting cytokines
play an important role in biological functions of Th17. At the same time, the activation of Th17 cells needs various growth factors, cytokines
such as IL-6 and IL-23, Th17 cell activated further promotes the secretion of various cytokines, and causes inflammation by secreting
cytokines such as IL-17, IL-21, IL-21, IL-26 and TNF-alpha. |
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