| 韩乃寒 刘映 赵燕英 陈娟 唐俊妮.金黄色葡萄球菌肠毒素研究进展[J].,2015,15(1):181-187 |
| 金黄色葡萄球菌肠毒素研究进展 |
| Review on Staphylococcus Aureus Enterotoxin |
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| DOI： |
| 中文关键词: 金黄色葡萄球菌 肠毒素 食物中毒 超抗原 |
| 英文关键词: Staphylococcus Aureus Enterotoxin Food poisoning Superantigen |
| 基金项目:国家自然科学基金项目（31371781）；教育部新世纪人才项目（NCET-11-0847） |
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| 中文摘要: |
| 金黄色葡萄球菌肠毒素是由金黄色葡萄球菌分泌的一类胞外毒素，其中传统型为SEA-SEE，具有催吐活性。目前也发现了
一些催吐活性未知的新类型肠毒素，命名为SEls。所有肠毒素的分子量都在22-28KDa 之间，由单一肽链组成，其稳定性好，可耐
大多数蛋白水解酶。金黄色葡萄球菌肠毒素具有较强的超抗原特性，可促使T 淋巴细胞大量增殖，同时表现出对组织相容性复合
物Ⅱ类分子(MHCⅡ)等位基因的不同偏爱性。超抗原的产生和调控依赖agr系统，同时也受其它因素的调控，如一些氨基酸。因此
在免疫治疗中具有着重要作用。本文从性质、组成、结构、功能、检测方法等方面对金黄色葡萄球菌肠毒素进行简要介绍，为肠毒
素的研究提供依据。 |
| 英文摘要: |
| Staphylococcus enterotoxins (SEs) are a series of exotoxin secreted by Staphylococcus with molecular weights of
22-28 kDa. They include the traditional kinds with the vomitting activity named SEA-SEE and the new kinds with the unknown
vomitting activity, which are named SEls. SEs are made of a single peptide chain. They can resist digestion by the most of proteolytic
enzymes. SEs belong to superantigen and can make T cells proliferate quickly. At the same time they show the different interaction with
the different histocompatibility complex Ⅱ class molecules (MHC Ⅱ) alleles. The expression of SEs is regulated by agr system and other
factors, such as the necessity of some amino acid. Due to the important role of SEs in immune therapy, they have grabbed the attention of
research scientists. Therefore, here we provide an overview of the characterististics, compositions, structures, functions and detecting
methods for SEs. |
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