| 吴兆利 李华栋 杨光 刘怀垒 申忱 邓一帆 彭飞 高大登 尹飞 赵博贤 赵世光.肿瘤干细胞及其模型的研究现状及临床治疗最新进展[J].,2015,15(1):178-180 |
| 肿瘤干细胞及其模型的研究现状及临床治疗最新进展 |
| The Cancer StemCell (CSC) and CSC Model |
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| DOI： |
| 中文关键词: 肿瘤干细胞 表型 治疗策略 异质性 |
| 英文关键词: Cancer StemCells Phenotype Therapeutic Strategies Heterogeneity |
| 基金项目:国家自然科学基金项目（81172388;30901533;30973078;81272788） |
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| 中文摘要: |
| 癌症发生最有名的模型之一肿瘤CSCcancer stem cell（CSC）模型已经被确立为一种细胞机制，有助于体现不同类型的肿瘤
表型和功能的异质性。然而，最新研究突出显示了肿瘤CSC 模型的复杂性和挑战性：CSC表型在不同的病人间有本质上的不同，
肿瘤可能含有多种表型或遗传上不同的CSC，转移的肿瘤CSC 可能由原始肿瘤CSC 进展而来，肿瘤细胞可进行可逆的表型的改
变。虽然在特定情况下，肿瘤CSC 的概念具有临床相关性，但越来越多的证据表明，定位、鉴定出肿瘤灶中所有亚型的肿瘤CSC
将对临床上预防肿瘤复发具有特殊意义。有以下几个因素可以促使异质性的发生：基因突变，后生的变化，与微环境间的相互作
用以及存在或缺失细胞分级等。肿瘤异质性可以用不同的细胞机制来解释。虽然CSC具有CSC 自我更新和分化的特性，但是它
们不一定是正常组织CSC转化而形成的。这种CSC 模型引起了科研工作者广泛的关注，我们结合新近的相关文献综述如下。 |
| 英文摘要: |
| The cancer stem cell (CSC ) model has been established as a cellular mechanism that contributes to phenoypic and
functional heterogeneity in diverse cancer types. Recent observations, however, have highlighted many complexities and challenges: the
CSC pheno type can vary substantially among patients, tumors may harbor multiple phenotypically or genetically distinct CSC, metastatic
CSC can evolve from primary CSC, and tumor cells may undergo reversible phenotypic changes. Although the CSC concept will have
clinical relevance in specific cases, accumulating evidence suggests that it will be imperative to target all CSC subsets within the tumo r
to prevent relapse. The following factors can cause the occurrence of heterogeneity: gene mutations, epigenetic changes, and the interaction
between the microenvironment and the presence or absence of cell fractionation, Tumor heterogeneity can be explained by different
cellular mechanisms. Although CSC has the characteristics of self-renewal and differentiation, they are not necessarily the conversion of
normal tissue CSC formed Scientists concerned about the cancer stemcell (CSC) model. We combine recent literature review are as follows. |
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