| 葛善珍 牛云彤 卢涛.皮肤刺激实验替代模型的研究新进展[J].,2015,15(1):167-170 |
| 皮肤刺激实验替代模型的研究新进展 |
| Progress of Research on the Skin Irritation Test Alternative Models |
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| DOI： |
| 中文关键词: 皮肤刺激实验 替代模型 组织工程 永生化细胞 丝素蛋白 |
| 英文关键词: Skin Irritation Test Alternative Model Tissue Engineering Immortized Cell Silk Fibroin |
| 基金项目:国家自然科学基金项目（81072964） |
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| 摘要点击次数: 798 |
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| 中文摘要: |
| 皮肤刺激性是日常使用化妆品最常见的不良反应之一。人类健康相关产品危险性评价常做皮肤刺激性实验, 皮肤刺激性试
验是化妆品原料及产品安全性评价的主要项目。传统皮肤刺激试验采用实验动物进行，2013 年3 月11 日欧盟已经禁止销售基于
动物实验研发的化妆品原料及产品.随着组织工程技术和现代生物技术的发展，多种替代动物试验的体外模型被开发和应用，新
的的皮肤刺激物陆续被发现。欧盟多采纳重组人表皮实验方法作为新体外皮肤实验指南(包括模型Episkin和模型Epiderm)，随着
体外模型重建技术的不断改善，不仅拓展了皮肤模型的临床应用范围,也必然推动新的敏感而特异的皮肤标志物的发现和应用。 |
| 英文摘要: |
| Skin irritation is one of the most common adverse reactions in daily using cosmetics. Risk assessment of Human
health related products often do skin irritation test, irritation test is the major projects to aspects of cosmetic of raw materials and product
safety assessment. Traditional skin irritation tests use experimental animals. EU ban on animal-tested cosmetics goes into force on 11
March 2013. With the development of the tissue engineering and modern biotechnology, number of alternative animal testing in vitro
models have been developed and applied, and new skin irritants were successively found. The EU adoption of experimental methods of
recombinant human epidermal skin in vitro experiments as a new guide, such as Episkin and Epiderm. With the improving of vitro model
recon-struction technology continues, the scope of the clinical application of skin model has been expanded, and it is bound to promote
the discovery and application of new skin sensitive and specific markers. |
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