| 孙馥箐 段华 汪沙.性激素对生殖系统Cx43 表达调控机制的研究进展[J].,2015,15(1):150-154 |
| 性激素对生殖系统Cx43 表达调控机制的研究进展 |
| Researches on Regulation Mechanismof Connexin 43 Expression inReproductive Systemby Sexual Hormones |
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| DOI： |
| 中文关键词: 性激素 间隙连接蛋白43 细胞间隙连接通讯 生殖系统 |
| 英文关键词: Sexual hormones Connexin43 Gap junction intracellular communication Reproductive system |
| 基金项目:国家自然科学基金项目(81270680) |
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| 中文摘要: |
| 由连接蛋白43 (connexin 43, Cx43) 构成的细胞间间隙连接(gap junction, GJ)是介导细胞间直接的物质、能量交换及电、化学
信号耦合的重要通路，其可保证细胞间功能活动的协调一致，在生殖系统细胞发育、分化及成熟等生理过程及功能活动中发挥非
常重要的调控作用。性激素可在转录及翻译等层面调节生殖系统细胞Cx43 的结构及表达，一方面通过核受体基因组机制调节
Cx43 基因的转录，另一方面通过非基因组快速信号传导通路机制调节Cx43 的磷酸化水平，共同影响细胞间隙连接通讯(gap
junction intracellular communication, GJIC)，进一步干预生殖系统细胞的病理、生理过程及功能活动。近年来，性激素在心血管系统
病生理状态下对连接蛋白调节的变化及机制研究较为成熟，而在子宫、卵巢等生殖器官中，对性激素通过调节连接蛋白及间隙连
接进而影响细胞间信息流通的研究较少，其作用机制并不清晰。故本文结合近年来文献，综述性激素对生殖系统细胞Cx43 表达
及GJIC 的调控机制的研究进展，旨在为今后深入地研究提供可行的思路。 |
| 英文摘要: |
| Gap junction (GJ) composed of connexin 43 (Cx43) is a kind of cell-cell junction which significantly mediates the direct
interchange of metabolites, energy and electrochemical signals from one cell to another. GJ ensures the coordination of intercellular
activities and plays a vital role in the regulation of cell development, differentiation, maturation and functional activities in the reproductive
system. Sexual hormones can influence the pathophysiological processes and functional activities of the reproductive cells by regulating
gap junction intracellular communication (GJIC), which depends on the expression of Cx43. On one hand, sexual hormones regulate
Cx43 gene transcription via the nuclear receptor mechanism, on the other hand, sexual hormones regulate Cx43 phosphorylation level
through the signal transduction pathways rapidly. Recently, in pathophysiological conditions of cardivascular system, the mechanisms of
sexual hormones regulating the expression of connexin and gap junction intracellular communication have been clearer through several
long-termresearches. However, there is lack of researches in the reproductive system. Therefore, on the basis of the recent researches, we
summarize the mechanisms on the expression of Cx43 and GJIC in the reproductive systemregulated by sexual hormones, laying the fundation
for further reseach. |
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