| 肖四海1 李莉1 宋巧凤1 张瑞荣1 江文艳1 郑翼2.冠心病患者的血浆大内皮素与N末端脑钠肽水平及其与心功能的关系[J].,2014,14(36):7076-7078 |
| 冠心病患者的血浆大内皮素与N末端脑钠肽水平及其与心功能的关系 |
| Relationships between Plasma Big endothelin,N Terminal Brain NatriureticPeptide and Cardiac Function of Patients with Coronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病 血浆大内皮素 N 末端脑钠肽 心功能 |
| 英文关键词: Coronary heart disease Big endothelin N terminal brain natriuretic peptide Cardiac function |
| 基金项目:唐山市科学技术研究与发展计划(12150220B-5）；国家自然科学基金项目(30900626) |
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| 中文摘要: |
| 目的：探讨冠心病(CHD)患者血浆大内皮素(Bigendothelin-1，BigET-1)与N末端脑钠肽(NT-proBNP)的水平及其与心功能的
关系。方法：选择本院2014 年1 月-2014 年5 月收治的60 例CHD患者为观察组，及同期接受体检的60 例健康志愿者作为对照
组，测定并比较两组的血浆大内皮素与N末端脑钠肽水平以及不同心功能分级CHD 患者的血浆大内皮素与N末端脑钠肽水平
的差异，分析血浆大内皮素与N 末端脑钠肽水平与CHD 患者心功能的关系。结果：观察组患者血浆Big ET-1 和NT-proBNP 的水
平均显著高于对照组，差异具有统计学意义(P<0.05)。随着CHD患者的心功能分级的增加，其血浆Big ET-1 和NT-proBNP的水
平逐渐升高，且各组之间比较差异均具有统计学意义(P<0.05)。血浆Big ET-1、NT-proBNP 水平与CHD 患者的心功能之间存在明
显的正相关性(P<0.05)。结论：CHD患者的血浆Big ET-1 与NT-proBNP水平均异常升高，且与患者的心功能呈正相关，监测其水
平对判断CHD的病情及心功能可能具有重要的临床参考价值。 |
| 英文摘要: |
| Objective:To investigate the relationships between plasma big endothelin, n terminal brain natriuretic peptide levels
and cardiac function of patients with coronary heart disease (CHD).Methods:60 cases of patients with CHD who were treated in our
hospital from January to May 2014 were selected as the observation group, while another 60 healthy volunteers were selected as the
control group. The plasma big endothelin and N terminal brain natriuretic peptide levels were determined and compared between the two
groups and between the CHD patients with different grades of heart function. The relationship between plasma big endothelin and N
terminal brain natriuretic peptide levels and the heart function of CHD patients were analyzed.Results:The plasma levels of BigET-1 and
NT-proBNP of observation group were significantly higher than those of the control group (P<0.05). The plasma levels of Big ET-1 and
NT-proBNP level increased gradually with the increasing of cardiac function grading of CHD patients (P<0.05). There were positive
correlations of the plasma levels of Big ET-1, NT-proBNP with cardiac function of CHD patients(P<0.05).Conclusion:The plasma levels
of BigET-1 and NT-proBNP of CHD patients were both upregulated, which were positively correlated with the cardiac function,
monitoring the plasma levels of BigET-1 and NT-proBNP could have important clinical reference value for determining the condition of
CHD and cardiac funciton. |
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