| 黄春月 陈文霞 朱伟良 孟辉 张健.小细胞肺癌分子标记物研究进展[J].,2014,14(33):6589-6591 |
| 小细胞肺癌分子标记物研究进展 |
| Research Progress of Molecular Markers in Small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 小细胞肺癌 分子标记物 神经内分泌肿瘤 预后评价 |
| 英文关键词: Small-cell lung cancer (SCLC) Molecular markers Neuroendocrine tumor Prognostic evaluation |
| 基金项目:广东省科技计划项目（2010B031600241） |
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| 中文摘要: |
| 肺癌仍然是现在最常见的恶性肿瘤之一。小细胞肺癌（Small cell lung cancer，SCLC）是肺癌中恶性程度最高的一种类型，与
吸烟密切相关，其较早发生远处转移和播散导致预后差，目前的主要治疗手段有手术、化学治疗、放射治疗。但其具有初始化放疗
敏感，却很快耐受的特点，导致了它总体预后不良，生存期短。如何寻求一种有效的疾病预后、疗效判断标记物，显得尤为重要。本
文主要介绍近年来在小细胞肺癌中分子标记物的研究进展，包括神经内分泌的相关蛋白、凋亡蛋白抑制剂（Survivin）、相关酶类及
膜蛋白，这些分子标记物与小细胞肺癌疾病的进展、预后密切相关，能够为临床的疾病治疗评估提供潜在可行的方法。但是，这些
标记物仍存在特异性不高的问题，最终应用于临床实践，仍需要更多的临床研究。 |
| 英文摘要: |
| Lung cancer is still one of the most commonly diagnosed malignancies. Small cell lung cancer is an aggressive form
of lung cancer that is strongly associated with cigarette smoking and has a tendency for early dissemination leading to poor prognosis.
The main treatment means are surgery, chemotherapy and radiotherapy. It has initial responses nearly invariably followed by rapid
recurrence of therapy-resistant disease resulting in poor survival rates. Now there is no available early detection strategy or targeted
therapy. Therefore, it is important to find out effective molecular markers which can evaluate disease prognosis and survival time. In this
review, we study the research progress of molecular markers in SCLC, including neuroendocrine related proteins, apoptosis protein
inhibitor (Survivin), relevant enzymes and membrane proteins. These molecular markers are closely associated with the development and
prognosis of SCLC. They may provide potential feasible method for clinical treatment. However, the specificity of these markers are still
not high enough and it also need more clinical studies for effective clinical application. |
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