| 樊秦娥 吴立兵 金琳 肖冰 余蓓蓓.降钙素原、IL-6 及CRP诊断新生儿宫内细菌感染的临床价值[J].,2014,14(33):6538-6540 |
| 降钙素原、IL-6 及CRP诊断新生儿宫内细菌感染的临床价值 |
| Effect of Procalcitonin Combined With IL-6 and C-reactive Protein inDiagnosis of Intrauterine Bacterial Infection in Neonates |
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| DOI： |
| 中文关键词: 降钙素原 C- 反应蛋白 白介素-6 新生儿宫内细菌感染 |
| 英文关键词: Procalcitonin C-reactive protein IL-6 Intrauterine bacterial infection |
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| 中文摘要: |
| 目的：探讨降钙素原、IL-6 及CRP 对新生儿宫内细菌感染诊断的临床价值。方法：采用回顾性分析方法，对121 例疑似宫内
细菌感染的新生儿的相关临床资料进行比较分析。通过影像学或细菌学方法对患儿进行检查判定感染类型，并检测患儿脐血中
的降钙素原、C- 反应蛋白（CRP）和白细胞介素-6（IL-6）的水平。结果：在121 例患儿中41 例确定为细菌感染，IL-6（>100ng/L）与
CRP（>10mg/L）联合对诊断新生儿宫内细菌感染的敏感性为90.1%，特异性为76.9%，阴性预测率为91.7%，阳性预测率为71.9%；
与PCT 结合后，诊断新生儿宫内细菌感染的敏感性升高至98.3%，特异性为67.8%，阴性预测率为99.2%，阳性预测率为57.0%。
结论：脐血PCT 可作为新生儿宫内细菌感染诊断的有效指标，可明显提高IL-6 与CRP诊断新生儿宫内细菌感染的阴性预测值和
敏感性，指导临床治疗。 |
| 英文摘要: |
| Objective:To evaluate the clinical value of procalcitonin combined with IL-6 and C-reactive protein in diagnosis of
intrauterine bacterial infection in neonates.Methods:The clinical date of 121 neonates who were suspected cases of intrauterine bacterial
infection were analyzed retrospectively. The level of PCT, IL-6 and CRP were detected and the intrauterine bacterial infection was
proved by imaging and bacteriology.Results:In 121 neoates, 41 children were confirmed as intrauterine bacterial infection. The
sensitivity value of IL-6 (>100ng/L) combined with CRP detection in diagnosis of NBI was 90.1%, the specificity was 76.9%, and the
negative predictive rate was 91.7%, the positive predictive rate was 71.9%. When IL-6 and CRP combined with PCT was used in
diagnosis of NBI, the sensitivity value was 98.3%, the specificity was 67.8%, the negative predictive rate was 99.2%, and the positive
predictive rate was 57.0%.Conclusion:PCT can be used as the auxiliary diagnosis of intrauterine bacterial infection, and can enhance the
negative predictive value and sensitivity of IL-6 combined with CRP in diagnosis of NBI. |
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