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目的：探讨组织相容性抗Ⅱ类HLA-DRB71 等位基因与原发性胆汁性肝硬化患者人群的相关性。方法：资料选自2011 年3 月-2013 年3 月在我院就诊的原发性胆汁性肝硬化患者95 例，健康人群203 例，分为原发性胆汁性肝硬化组与健康人群组，皆予以序列特异性引物PCR分析，对两组的等位基因进行分析研究。结果：原发性胆汁性肝硬化组DRB71* 07 基因频率为36.84%，高于健康人群组13.79%，差异具有统计学意义（P<0.05）；原发性胆汁性肝硬化组其他基因低于健康人群组，差异无统计学意义（P>0.05）；DRB71* 07 OR 值是2.67，表明原发性胆汁性肝硬化组DRB71* 07 阳性率与健康人群组相比较，是其2.67 倍，比值差异具有统计学意义（P<0.05）；原发性胆汁性肝硬化患者易感性与DRB71* 0701 高度相关。结论：中国原发性胆汁性肝硬化患者可能同DRB71* 0701 较易感染有密切关系，为其临床的治疗提供线索。

英文摘要:

Objective:To study the histocompatibility of Ⅱ class a DRB71 HLA alleles and the correlation of primary biliary cirrhosis patient popurlation.Methods:95 cases of primaryliver juice cirrhosis patients and 203 cases of healthy people in our hospital from March 2011 to March 2013 were divided into primary liver juice cirrhosis group and healthy group, sequence specific primer PCR analysis was conducted to analyze the alleles of the two groups.Results:Primaryliver juice cirrhosis group DRB71*07 gene frequency was 36.84%, 13.79% higher than that of the healthy group, and the difference was statistically significant ( P< 0.05); Primaryliver juice cirrhosis group of other genes was lower than the healthy group, but there was no statistically significant difference ( P>0.05); DRB71 * 07 OR value was 2.67, which indicates that primary liver juice cirrhosis group DRB71 * 07 positive rate compared with healthy group, is the 2.67 times ratio difference statistically significant (P<0.05); Suscep tibility to primary liver juice cirrhosis patients with DRB71 * 0701 highly correlated.Conclusion:Chinese patients with primary biliary cirrhosis may have close relationship with infection more easily DRB71*0701, which may provide a clue for its dinical treatment.

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