| 谢克莱·吾普尔 买苏木·买合木提 王宝珠 阿米娜 迪丽达尔.氯沙坦早期联合美托洛尔治疗高龄重症心力衰竭的疗效[J].,2014,14(30):5966-5969 |
| 氯沙坦早期联合美托洛尔治疗高龄重症心力衰竭的疗效 |
| The Effect of Losartan Combined with Metoprolol in the Treatmentfor Senile Patients with Severe Heart Failure |
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| DOI： |
| 中文关键词: 重症心力衰竭 高龄患者 氯沙坦 美托洛尔 |
| 英文关键词: Severe chronic heart failure Senile patients Losartan Metoprolol |
| 基金项目: |
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| 中文摘要: |
| 目的：研究氯沙坦早期联合美托洛尔治疗高龄重症心力衰竭的临床疗效。方法：选取2010 年1 月至2013 年1 月本院住院
治疗的60 例高龄重症心力衰竭患者，采用随机数字表法随机分为氯沙坦联合美托洛尔治疗组、氯沙坦治疗组和对照组，每组患
者20 例；所有患者均采取常规治疗，对照组加用口服强心剂和利尿剂，氯沙坦治疗组在常规治疗的基础上加用氯沙坦，氯沙坦联
合美托洛尔治疗组在常规治疗的基础上加用氯沙坦和美托洛尔，在治疗前及治疗后0.5a、1.0a 检测所有患者的心功能、左室射血
分数(LVEF)和血液中的B 型脑钠肽（BNP），并观察治疗后1.0a 的临床疗效。结果：治疗前三组患者的心功能、左室射血分数
（LVEF）以及B型脑钠肽（BNP）间均无统计学差异（P>0.05）；氯沙坦治疗组、氯沙坦联合美托洛尔治疗组治疗后0.5a 和1.0a 的心
功能和BNP 均低于对照组（P<0.05），而治疗后0.5a 和1.0a 的LVEF 均高于对照组（P<0.05）；氯沙坦联合美托洛尔治疗组治疗后
0.5a 的心功能、LVEF以及BNP与氯沙坦治疗组无统计学差异（P>0.05），而氯沙坦联合美托洛尔治疗组治疗后1.0a 的心功能、
LVEF 以及BNP 与氯沙坦治疗组均存在着统计学差异（P<0.05）；三组治疗后1.0a 死亡率间存在统计学差异（P<0.05）；每年住院
次数和平均住院日最少的是氯沙坦联合美托洛尔治疗组，其次为氯沙坦组。结论：氯沙坦与美托洛尔早期联合治疗高龄重症心力
衰竭的疗效优于氯沙坦单独治疗。 |
| 英文摘要: |
| Objective:To investigate the clinical effect of losartan combined with metoprolol in the treatment for senile patients
with severe heart failure.Methods:60 cases of senile patients with severe heart failure in our hospital from January 2010 to January 2013
were chosen and randomly divided into three groups via randomnumber table method: losartan combined with metoprolol therapy group,
losartan therapy group and control group, each group with 20 patients. All patients were given routine treatment, the control group was
given oral cardiac and diuretic, the chlorine therapy group take chlorine and the losartan with metoprolol therapy group take losartan and
metoprolol. The cardiac function, left ventricular ejection fraction (LVEF) and b-type brain natriuretic peptide (BNP) in 0.5A, 1.0A
before and after the treatment were detected and the clinical effect at 1.0a after treatment were observed.Results:The cardiac function,
left ventricular ejection fraction (LVEF) and b-type brain natriuretic peptide (BNP) has no significant statistical differences among three
groups before therapy (P>0.05); The cardiac function and BNP of the losartan with metoprolol therapy group and the losartan therapy
group after 0.5a and 1.0a were lower than that of the control group, while LVEF was higher in control group (P<0.05); The cardiac
function, LVEF and BNP after 0.5a had no significant statistical differences between the losartan with metoprolol therapy group and the
losartan therapy group (P>0.05), but three indicators after 1.0a has significant statistical differences(P<0.05); The mortality rates for these
three groups after 1.0a had statistical differences（P<0.05）; The losartan with metoprolol therapy group had the least annual average
hospitalization time, followed by the losartan therapy group.Conclusion:Better effect can be achieved via losartan combined with
metoprolol in the treatment for senile patients with severe heart failure. |
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