| 曾祥伯 贵建平 邓建华 何东 李娜.sTREM-1、PCT在社区获得性肺炎早期诊断中的价值[J].,2014,14(30):5947-5950 |
| sTREM-1、PCT在社区获得性肺炎早期诊断中的价值 |
| Significance of Soluble Triggering Receptor Expressedon Myeloid Cells-1 and Procalcitonin in the Early Diagnosisof Community-acquired Pneumonia |
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| DOI： |
| 中文关键词: 社区获得性肺炎 可溶性髓系细胞触发受-1 降钙素原 |
| 英文关键词: Community-acquired pneumonia Soluble triggering receptor expressed on myeloid cells-1 Procalcitonin |
| 基金项目:湖南省医药卫生科研计划课题项目(B2008-045) |
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| 中文摘要: |
| 目的：探讨可溶性髓系细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-1，sTREM-1)、降钙素原(procalcitonin，
PCT)在社区获得性肺炎(community-acquired pneumonia，CAP)早期诊断中的价值。方法：选择48 例CAP 住院患者(其中重
症肺炎8 例)和病毒性上呼吸道感染患者20 例，所有病例均在入院后24 小时内取血清，采用酶联免疫测定法(ELISA法)测定其
血清sTREM-1、PCT 水平，并应用受试者工作特征曲线(receiver operating characteristic curve，ROC 曲线)分析二者对CAP 的诊断
价值。结果：入院后24 小时内，普通肺炎患者、重症肺炎患者血清sTREM-1、PCT 水平均明显高于对照组，且重症肺炎组明显高于
普通肺炎组，差异均具有统计学意义(P<0.01)。二者诊断CAP的ROC曲线下面积分别为0.884、0.788，联合二者诊断CAP 的ROC
曲线下面积为0.921。结论：sTREM-1、PCT 均可作为CAP 早期诊断有价值的参考标志物，sTREM-1 比PCT 更有参考价值，联合
检测血清sTREM-1、PCT 水平对CAP 的早期诊断价值高于单一指标。 |
| 英文摘要: |
| Objective:To investigate the value of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and
procalcitonin (PCT) in early diagnosis of community-acquired pneumonia.Methods:48 inpatients with pneumonia (include 8 patients
with severe pneumonia) and 20 patients with Viral upper respiratory tract infection as control were included. Serum sTREM-1 and PCT
were detected by enzyme-linked immunosorbent assays(ELISA) within 24 hours. The receiver operating characteristic curve(ROC curve)
was used to check diagnostic value of the detections.Results:The concentrations of sTREM-1 and PCT in serum were significantly
hisher than those in controls with Statistical significance. The concentrations of sTREM-1 and PCT in severe pneumonia group were
significantly hisher than those in common pneumonia group with Statistical significance. The area under the ROC curve of sTREM-1,
PCTwere respectively 0.884, 0.788, which was 0.921 by combination of sTREM-1 and PCT.Conclusion:Both sTREM-1 and PCT are good
markers in the early diagnosis of CAP, combined detection of serumsTREM-1, PCT levels was more valuable for early diagnosis of CAP. |
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