| 孙坚 邓杰 毕胜 杨海波 李著.AEBP1 在结直肠癌中的表达及其意义[J].,2014,14(29):5727-5730 |
| AEBP1 在结直肠癌中的表达及其意义 |
| Expression of AEBP1 in Colorectal Adenocarcinoma and its ClinicalSignificance |
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| DOI： |
| 中文关键词: 结直肠肿瘤 脂肪细胞增强结合蛋白1 病理学 临床 |
| 英文关键词: Colorectal neoplasms Adipocyte enhancer-binding protein 1 Pathology Clinical |
| 基金项目: |
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| 中文摘要: |
| 目的：研究脂肪细胞增强结合蛋白1（AEBP1）在结直肠癌组织中的表达情况，以探索其临床意义。方法：运用免疫组织化学
和实时定量PCR 技术，对AEBP1 在结直肠癌中的表达情况进行检测，并分析其表达量与患者临床病理特征的关系。结果：AEBP1
在结直肠正常组织、腺瘤和癌组织中的免疫评分有明显差异（P<0.05），而且AEBP1 的阳性表达与肿瘤的分期和浸润深度明显相
关。基因水平AEBP1 的表达在肿瘤组织中明显高于正常组织。结论：AEBP1 在结直肠癌组织中存在异常表达，并且可能是结直肠
癌早期诊断和浸润深度的肿瘤标志物。 |
| 英文摘要: |
| Objective:To investigate the association between the expression of Adipocyte enhancer-binding protein 1 (AEBP1)
and the clinicopathological characteristics of CRC patients in order to find out the clinical significance of this protein.Methods:The
AEBP1 expression levels were determined by immunohistochemistry and qPCR. The relationship of the expression of AEBP1 and
clinicopathological characteristics was analyzed.Results:There were significant difference of the AEBP1 expression in CRC tissues and
Adenoma tissues compared with Normal tissues (P<0.05); the expression of AEBP1 was correlated with TNM staging and tumor
invasion. Moreover, AEBP1 mRNA expression levels were also significantly different between CRC tissues and their corresponding
normal tissues.Conclusion:Our results indicate that AEBP1 protein expression is aberrantly detected in CRC tissues, and has potential
value of biomarker for CRC early detection and tumor invasion. |
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