| 张晓敏 董秀帅 刘娟 陈曦 王京华.COVDP方案治疗成人急性淋巴细胞白血病疗效分析[J].,2014,14(28):5476-5478 |
| COVDP方案治疗成人急性淋巴细胞白血病疗效分析 |
| Analysis on the Effect of COVDP for Treatment in Adult AcuteLymphoblastic Leukemia |
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| DOI： |
| 中文关键词: 急性淋巴细胞白血病 诱导缓解 化疗 成人 |
| 英文关键词: Acute lymphocytic leukemia Remission induction Chemotherapy Adult |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨不同诱导方案治疗成人急性淋巴细胞自血病的疗效及合并症情况。方法：采用COVDP 及DVLP诱导治疗方案
将我科（2005-2011 年）62 例急性淋巴细胞白血病患者分为两组，A 组采用COVDP诱导方案，B 组采用DVLP诱导方案。比较两
种不同诱导方案治疗成人急性淋巴细胞白血病的初治缓解率、感染率、是否延迟化疗及骨髓抑制时间。结果：两组方案骨髓缓解
率差异无统计学意义（P>0.05），巩固治疗期间感染率差异有统计学意义（P<0.05），A 组骨髓抑制时间为（15.51± 0.82d）长于B 组
（9.63± 0.71 d）（P<0.05），A 组化疗延迟率为44.5％，高于B 组（23.1％）（P<0.05）。结论：与COVDP 诱导方案相比，DVLP诱导方
案缩短了骨髓造血恢复时间，降低了感染率及化疗合并症的发生。 |
| 英文摘要: |
| Objective:To explore the curative effect and complcations of different induction programme in adult acute
lymphoblastic leukemia.Methods:62 acute lymphoblastic leukemia patients (2005-2011) were divided into two groups. Group A
received COVDP plan, and group B received DVLP plan. The initial remission rate, the infection rate, whether or not to delay
chemotherapy and the bone marrow suppression time were studied between the two groups.Results:The initial remission rates were not
significant between the two groups (P>0.05). The infection rates were significant during consolidation therapy (P<0.05). The bone
marrow suppression time in group A (15.51± 0.82d) was longer than that in group B (9.63± 0.71d). The delay rate of chemotherapy was
higher in group A (44.5％) was longer than that in group B (23.1％) (P<0.05).Conclusion:Compared to the plan of COVDP, the plan of
DVLP shortened the bone marrow recovery time and reduced the rates of infection and complications. |
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