| 肖燎原 盛珺 郁胜强 王鹏 梅长林.常染色体显性多囊肾病合并颅内动脉瘤的临床特征及其随访研究[J].,2014,14(28):5468-5472 |
| 常染色体显性多囊肾病合并颅内动脉瘤的临床特征及其随访研究 |
| Observation on the Clinical Characteristics and Follow-up of AutosomalDominant Polycystic Kidney Combined with Intracranial Aneurysms |
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| DOI： |
| 中文关键词: 常染色体显性多囊肾病 颅内动脉瘤 筛查 随访 |
| 英文关键词: ADPKD ICA Screening Follow-Up |
| 基金项目:上海市科委重点科技攻关项目（11431920800） |
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| 中文摘要: |
| 目的：探讨常染色体显性多囊肾病(Autosomal dominant polycystic kidney disease，ADPKD)合并颅内动脉瘤的临床特征及其
预后情况。方法：选择355 例2007 年11 月至2008 年11 月上海长征医院收治的被诊断为ADPKD的患者为研究对象，分析其临
床资料及头部动脉瘤MRA筛查的结果，并对合并颅内动脉瘤的患者进行随访。结果：355 例ADPKD患者颅内动脉瘤的发病率为
12.4%，发病率随年龄的增加而升高，60-69 岁组的发病率为23.3%，有脑卒中家族史的患者发病率明显高于无明确脑卒中家族史
的患者(P<0.05)。大部分动脉瘤较小(平均直径3.85± 3.25mm)，且都位于前循环，其中颈内动脉最常见(占48.1%)。对44 位合并颅
内动脉瘤的患者进行随访，共随访21 位患者(27 枚动脉瘤)，平均随访43.5± 4.3 月，未发现新生动脉瘤；2 枚动脉瘤有明显增大，
扩大率为7.4%，其余25 枚动脉瘤无明显增大，无动脉瘤破裂。结论：年龄≥ 30 岁和具有脑卒中家族史的ADPKD患者易并发颅
内动脉瘤，大多直径较小且位于前循环，随访期间大多无明显增大或破裂。 |
| 英文摘要: |
| Objective:To Iinvestigate the clinical characteristics and prognosis of autosomal dominant polycystic kidney disease
(ADPKD) with intracranial aneurysm(ICA).Methods:Patients who were diagnosed as ADPKD fromNovember 2007 to November 2008
in CHANG ZHENG hospital were selected as research objects. Their clinical data and MRI data were collected and analyzed, and
patients with ICA were followed up (recheck MRI and collect clinical data).Results:355 patients with ADPKD were found. The
incidence rate was 12.4%, which increased as the age increased, reaching a peak value of 23.3% in the 60-69 year age group. The
incidence rate of ICA in patients with ADPKD with a positive family history of hemorrhagic stroke was higher than that lack such family
history (P<0.05). Most aneurysms were small (median diameter 3.85± 3.25 mm) and all in the anterior circulation, the most common
location was in internal carotid artery (48.1%).21 patients, 27 aneurysms had imaging follow-up. During cumulative imaging follow-up of
43.5± 4.3 months, no de novo UIA was detected and two ICA grew obviously with enlargement rate was 7.4%. No evident change was
detected in the remaining 25 aneurysms, no aneurysm ruptured.Conclusion:Patients whose age were older than 30 or had family history
of hemorrhagic stroke were pretended to suffer from ICA. Most ICAs were small and located in the anterior circulation, during the
duration of followed-up, the majority of ICA hadn't enlarged and ruptured. |
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