| 陈宇亮 张亚楠 张智瑞 张婷 李润平.腺苷在癫痫发病机制中的作用以及腺苷相关癫痫治疗的研究进展[J].,2014,14(26):5180-5183 |
| 腺苷在癫痫发病机制中的作用以及腺苷相关癫痫治疗的研究进展 |
| The Recent Researches of the Effect of Adenosine in EpilepticPathogenesis and Therapy |
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| DOI： |
| 中文关键词: 腺苷 癫痫 星形胶质细胞 腺苷激酶 中枢神经系统 |
| 英文关键词: Adenosine Epilepsy Astrocyte Adenosine kinase(ADK) Central nervous system(CNS) |
| 基金项目:国家自然科学基金项目(81272179) |
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| 中文摘要: |
| 癫痫是慢性反复发作性的脑功能失调综合征，近年来，关于星形胶质细胞及腺苷和癫痫关系的研究逐渐成为热点。腺苷在
中枢神经系统中广泛存在，其可以作为整合中枢兴奋性以及抑制性神经递质的调节因子，其诸多生理作用都是通过受体介导实
现的。研究腺苷通过星形胶质细胞及腺苷激酶、谷氨酸、表观遗传基因修饰、伽马氨基丁酸受体等通路在抑制癫痫发病机制中的
作用，将为治疗癫痫提供全新的治疗思路和措施。本文将针对腺苷抑制癫痫发生的机制以及目前与腺苷有关的癫痫治疗方法进
行综述。如果在今后的研究工作中能够进一步明确腺苷在抑制癫痫中的作用机制，就有可能寻找新的干预靶点，对发展新的预防
措施，指导预防药物研发，都具有重要意义。 |
| 英文摘要: |
| Epilepsy is a chronic and recurrent syndrome of cerebral dysfunction. Recently, the relationship between epilepsy and
astrocyte or adenosine has become a research hotspot. Adenosine is recognized as the modulator of central nervous system excitability
and plays a key role in depressing neuronal transmission by combining its receptor. Researching the relationship of adenosine and
astrocyte, adenosine kinase(ADK), Epigenetic modifications or GABAAR can provide a new and challenging therapy of epilepsy. In this
paper, we will summarize the recent researches of the effects of adenosine in epileptic pathogenesis and therapy. If the clear mechanism
of how adenosine inhibits epilepsy can be found in the future researches, we will have the new targets to aimat and it will have important
implications for the researches and developments of precautionary measures and medicine. |
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