| 谭钧文 原劲杨 王涌泉 安瑞华 林洋.LIVIN 和HLA-I类分子在肾透明细胞癌中的表达及其临床意义[J].,2014,14(25):4883-4886 |
| LIVIN 和HLA-I类分子在肾透明细胞癌中的表达及其临床意义 |
| Expression and Clinical Significance of LIVIN and HLA-I in the Clear CellRenal cell Carcinomas |
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| DOI： |
| 中文关键词: Livin HLA I类分子 肾透明细胞癌 免疫组织化学 免疫治疗 |
| 英文关键词: Livin HLA-I Clear cell renal cell carcinoma Immunohistochemistry Immunotherapy |
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| 中文摘要: |
| 目的：探讨凋亡抑制蛋白Livin 与人类白细胞抗原(HLA)I类分子在人类肾脏透明细胞癌(clear cell renal cell carcinoma，ccRCC)
中的表达及其临床意义。方法：选择哈尔滨医科大学附属第一医院2007 年12 月至2011 年12 月收治的拟行肾癌根治术的患
者80 例，应用免疫组织化学方法检测80 例ccRCC 组织与10 例癌旁正常肾组织中Livin 及HLA-I类分子的表达，并分析其与患
者临床病理特征之间的关系。结果：10 例癌旁正常肾组织中均未见Livin 的阳性表达，而HLA-I类分子的阳性表达率为100 %。
ccRCC 组织中，Livin 的阳性表达率及HLA I类分子表达下调百分率分别为41(51.25 %)例和48(60.00 %)例，Livin 的阳性表达率
与正常组相比差异有统计学差异(P<0.05)。ccRCC 组织中Livin 的阳性表达率与淋巴结转移、组织分化程度显著相关(P<0.05)，而
HLA I类分子的表达下调百分率与患者的性别、年龄、肿瘤分级、淋巴结转移及分期均无相关性(P>0.05)。ccRCC组织中Livin 的
表达与HLA I类分子的表达亦无显著相关性(P>0.05)。结论：Livin、HLA I类分子表达异常参与了ccRCC 的发生、发展过程，Livin
可能成为ccRCC的一个重要预后指标和治疗靶点。 |
| 英文摘要: |
| Objective:To study the expression and clinical significance of Livin andHLA-I in clear cell renal cell carcinoma(ccRCC).Methods:80 patients who underwent radical nephrectomy from December 2007 to December 2011 in the First Affiliated Hospital of
Harbin Medical University were selected. Immunohistochemical staining was used to determine the expression of Livin and HLA-I in 80
cases of ccRCC tissues and 10 cases of normal renal tissues, and analyze its relationship with clinicopathological features of patients.Results:The positive rate of Livin was 0 %while HLA-I was expressed in all normal renal tissues. Livin was expressed in 41 (51.25 %) of
80 renal cancer tissues, and the expression of HLA-I was down-regulated in 48 (60.00 %)specimens. The expression of Livin in ccRCC
was associated with the metastasis and the degree of tissue differentiation, but the expression of HLA-I had no correlation with age, sex,
TNM stage or Lymphatic metastasis. The expression of Livin was not correlated with that of HLA-I in ccRCC.Conclusion:Livin and
HLA-I may play an important role in the occurrence and progression of ccRCC, Livin may be important diagnostic／therapeutic indicator
or target in ccRCC. |
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