| 唐念中 陈少萍 王君 赵仙先 郑兴.不同剂量ASA对PCI术后患者血浆TXB2 和P选择素水平的影响[J].,2014,14(25):4869-4872 |
| 不同剂量ASA对PCI术后患者血浆TXB2 和P选择素水平的影响 |
| Effect of the Different Doses of Aspirin on the Levels ofTXB2 and P-Selectin in Plasma after PCI |
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| DOI： |
| 中文关键词: 阿司匹林 PCI术 TXB2 P 选择素 |
| 英文关键词: Aspirin Percutaneous coronary intervention TXB2 P-selectin |
| 基金项目:上海市自然科学基金项目(10411954900) |
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| 中文摘要: |
| 目的：经皮冠脉介入治疗(PCI)术后阿司匹林的剂量一直是人们争论的问题。虽然国外多个大型临床研究发现PCI术后服用
低剂量阿司匹林（≤ 100 mg/d）较高剂量阿司匹林（300 mg/d）可同样预防缺血事件，而且还可以减少出血事件的发生，但这些研究
均未对不同剂量阿司匹林抑制血小板聚集及活化情况进行检测，我们通过对PCI 术后服用不同剂量阿司匹林患者血浆中血栓烷
素B2（TXB2）和P选择素的水平的检测，为PCI术后阿司匹林合理剂量提供更有力的依据。方法：我们于2011年5 月至2012 年
12 月间，连续入选在我院行冠状动脉造影并置入了支架且符合入选标准的患者150 例，随机分为低剂量阿司匹林组（PCI术后阿
司匹林100 mg/d）和高剂量阿司匹林组（PCI 术后阿司匹林300 mg/d 服用3 个月后改100 mg/d），采用酶联免疫吸附双抗体夹心
法分别于服用阿司匹林前以及PCI术后5-7 天检测血浆中TXB2 、P 选择素水平。结果：与服用阿司匹林前相比，服用阿司匹林
后，各组血浆中TXB2 和P选择素均有明显下降，PCI 术后两组间血浆中TXB2 和P选择素的水平均无显著差异。结论：PCI术后
低剂量阿司匹林（≤ 100 mg/d）抑制血小板聚集及活化的效果与高剂量阿司匹林（300 mg/d）相同。 |
| 英文摘要: |
| Objective:There is a dispute on the optimal dose of aspirin following PCI. In recent years, several large-scale clinical
trials abroad shows that that comparing a higher dose of aspirin (300 mg/day), taking low-dose aspirin (≤ 100 mg/day) after PCI not only
has the effect of preventing ischemic events, but also can reduce the incidence of bleeding. But these studies did not detect the effects of
different doses on inhibition of platelet aggregation andplatelet activity, We check the levels of TXB2 and P-selectinin plasma of the patients
who receive various doses aspirin after PCI, and provide the basis for the the optimum doses of aspirin after PCI.Methods:We recruited
150 patients consecutive who have undergone the percutaneous coronary intervention in cardiology department of Changhai Hospital
from May 2011 to December 2012. The patients were randomly assigned to low-dose (100 mg daily) after PCI verse high-dose (300
mg for 3 month after PCI then 100mg daily) aspirin, theassay of enzyme linked immunosorbent was used in checking the levels of TXB2
and P- selectin before taking aspirin and at 5-7 days after PCI respectively in plasma.Results:Aftering taking different doses of Aspirin,
the level of TXB2 and P-selectin of each group has a significantly decreese, and there were no significant differences between two groups
inthe levels of TXB2 and P-selectin after PCI.Conclusion:the low-dose aspirin has the same effect as high-dose of aspirin on inhibition
of platelet aggregation andplatelet activity after PCI. |
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