| 陈茜 柴程芝 寇俊萍 余伯阳.缺氧诱导肺损伤的病理机制研究进展[J].,2014,14(23):4566-4569 |
| 缺氧诱导肺损伤的病理机制研究进展 |
| Advances on the Pathomechanism of Hypoxia-induced Injury of Lung |
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| DOI： |
| 中文关键词: 缺氧 氧化应激 炎症反应 肺损伤 |
| 英文关键词: Hypoxia Oxidative stress Inflammatory response Lung injury |
| 基金项目:“十一五”国家科技支撑计划（2008BAI151B03）；江苏省科技支撑计划临床医学科技专项(BL2012060)；
中央高校科研专项基金（JKP2011011） |
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| 中文摘要: |
| 大量研究表明，缺氧造成的肺部代谢功能障碍能够诱导肺组织损伤，最终导致慢性阻塞性肺炎、肺动脉高压等呼吸系统疾
病。缺氧引起的氧化应激反应及炎症反应是诱导肺损伤的关键环节，而这些反应与缺氧后激活的活性氧自由基、一氧化氮合酶、
细胞因子及NF-κB 通路等都有密切联系。国内外学者在这方面进行了大量研究并取得了重要进展，本文就近5 年的国外文献报
道进行综述。 |
| 英文摘要: |
| Abundant studies have shown that hypoxia can cause lung metabolic dysfunction which can induce lung tissue
damage, eventually leads to respiratory diseases, such as chronic obstructive pulmonary disease, pulmonary hypertension and so on.
These symptoms have a close association with the body's own oxidative stress response and the inflammatory response, which include
activation of reactive oxygen species, Nitric-Oxide synthase, cytokine and NF-κB. Domestic and foreign scholars have conducted
extensive research in this area and have made important progresses. In this paper, the recent studies on relationship of hypoxia and the
lung injury were reviewed in the last five years. |
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