| 张勇 孙灵丽 李涛 肖玉 张琴.小儿肺炎支原体感染后免疫功能的变化规律及其临床意义[J].,2014,14(22):4346-4348 |
| 小儿肺炎支原体感染后免疫功能的变化规律及其临床意义 |
| The Change and Clinical Significance of Immune Function in Children withMycoplasma Pneumoniae Infection |
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| DOI： |
| 中文关键词: 小儿肺炎 支原体感染 免疫功能 变化规律 临床意义 |
| 英文关键词: Pneumonia Mycoplasma infection Immune function Variation Clinical significance |
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| 中文摘要: |
| 目的：探讨小儿感染肺炎支原体后对免疫功能的影响，总结其变化规律及其临床意义。方法：选择2009 年12 月至2011 年
12 月我院收治的55 例肺炎支原体感染患儿作为观察对象，设为观察组，选择同期50 例健康儿童作为对照，设为对照组。采用细
胞酶免疫分析法测定T 淋巴细胞亚群以及淋巴细胞表面标记表达，对比两组患儿相关指标差异。结果：观察组患儿体内的IgG 和
IgA水平分别为（8.24± 1.2）g/L 和（1.64± 0.62）g/L，显著低于对照组，差异均有统计学意义（均P<0.05）；观察组T 细胞亚群指标
中CD3+、CD4+水平分别为（62.24± 6.25）%和（40.62± 5.02）%，显著低于对照组，差异均有统计学意义（均P<0.05）；观察组CD8+
有所提升，CD4+/CD8+比值显著降低，与对照组相比，差异明显（P<0.05）。结论：小儿感染肺炎支原体后细胞免疫系统明显受到抑
制，B 淋巴细胞部分失调，掌握此规律有助于为临床治疗。 |
| 英文摘要: |
| Objective:To investigate the effect of immune function of children with mycoplasma pneumonia infection, to
summarize the changes and its clinical significance.Methods:55 cases of children with mycoplasma pneumonia infection fromDecember
2009 to December 2011 in our hospital were selected as the observation objects, set as observation group, and during the same period, 50
healthy children were selected as control group. Expression of Tlymphocyte subsets and lymphocyte surface marker analysis by cell
ELISA, compared the correlation index difference of two groups.Results:IgG and IgA levels in observation group were (8.24 ± 1.2)g/L
and (1.64 ± 0.62)g/L, significantly lower than control group, the differences were statistically significant (P<0.05); CD3+, CD4+ level of T
cell subsets in observation group were (62.24± 6.25)%and (40.62± 5.02) %, significantly lower than control group, the differences were
statistically significant (P<0.05); CD8+ in observation group increased, CD4+/CD8+ ratio significantly decreased, compared with that in
control group, it had significant difference (P<0.05).Conclusion:Cells of the immune system in children infected with mycoplasma
pneumoniae was significantly inhibited with Blymphocyte dysfunction, master this rule is helpful to clinical treatment. |
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