| 蒋珍妮 林青 齐春华 崔春晓 费杰 边甜甜.乳腺癌HER2 表达与乳腺X线及超声影像表现的相关性分析（英文）[J].,2014,14(22):4237-4243 |
| 乳腺癌HER2 表达与乳腺X线及超声影像表现的相关性分析（英文） |
| Analysis of Breast Cancer: HER2 Expression and Imaging Findingson Mammography and Ultrasound |
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| DOI： |
| 中文关键词: 乳房X 线摄影术 超生 乳腺肿瘤 受体, erbB-2 |
| 英文关键词: Mammography Ultrasonography Breast neoplasm Receptor, erbB-2 |
| 基金项目:青岛市公共领域科技支撑计划[2012-1-3-2-(8)-NSH] |
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| 中文摘要: |
| 目的：对比分析乳腺癌人类表皮生长因子受体2(human epidermal growth factor receptor 2，HER2)表达阳性和阴性与乳腺癌
的X 线及超声影像表现的相关性。方法：对139 例雌激素受体（oestrogen receptor ER）、孕激素受体（progesterone receptor PR）表达
均阴性的乳腺癌患者术前行X线及超声形态学分析，术后标本测定癌细胞的人类表皮生长因子受体2（HER2）表达情况，比较并
分析HER2+/ER-/PR- 乳腺癌和HER2-/ER-/PR- 乳腺癌影像学的特征性表现，在X 线上主要分析: 腺体致密度、及病变类型（肿块、
钙化、结构紊乱）。其中肿块主要分析形状、边缘、大小；钙化主要分析形态、分布，在超声上主要分析：肿块边缘、有无强回声点、有
无腋淋巴结转移，血流情况。结果：HER2+/ER-/PR- 乳腺癌在X 线上的特征性表现为单纯肿块（x2=8.067，P=0.005）或肿块伴钙化
（x2=4.384，P=0.036），棒状、分枝状钙化（x2=5.723，P=0.017），簇状分布（x2=12.110，P=0.007），肿块直径多＞2cm（x2=4.933, P=0.
026），而在腺体致密度、肿块边缘方面差异无统计学意义。超声的特征性表现为肿块伴钙化(x2=16.134，P<0.001)、边界不清(x2=9.
188，P=0.010)、伴腋下淋巴结转移(x2=5.210，P=0.022)，血流方面差异无统计学意义。结论：HER2+/ER-/PR- 乳腺癌影像学有特征
性表现，X 线常表现为单纯肿块或肿块伴钙化，棒状、分枝状钙化，簇状分布，肿块直径多＞2cm；超声常表现为低回声肿块、边界
不清、其内可见点状强回声、常伴腋下淋巴结转移。 |
| 英文摘要: |
| Objective:To comparatively analyze the correlation between positive and negative expressions of human epidermal
growth receptor2 (HER2) and mammography and ultrasound imaging manifestations.Methods:139 breast cancer patients with expressions
of oestrogen receptor (ER) and progesterone receptor (PR) were analyzed through mammography and ultrasound morphology
before surgery, and expression of HER2 were detected after surgery. The characteristic imaging manifestations were also compared and
analyzed between HER2+/ER-/PR- breast cancer group and HER2-/ER-/PR- breast cancer group. The main aspects on mammography
contain gland density and lesion type (mass, calcification or structure disturbance). Mass was analyzed by margin and size. And calcification
was analyzed by morphology and distribution. Main analyses on ultrasound were margin, with or without hyperecho focus and axillary
lymph nodes metastasis, blood flow signal.Results:The characteristic manifestations of breast cancer with HER2+/ER-/PR- on
mammography were simple mass（x2=8.067, P=0.005）or mass with calcification（x2=4.384, P=0.036）, calcification usually show rodlike
or branching calcification（x2=5.723，, P=0.017）, with clustered distribution（x2=12.110, P=0.007）. Most diameters of mass were >2cm
（x2=4.933, P=0.026）. The characteristic manifestations of ultrasound were mass with calcification (x2=16.134, P<0.001), unclear margin
(x2=9.188, P=0.010), combined with axillary lymph nodes metastasis (x2=4.069, P=0.044).Conclusion:In hormone receptor negative cases,
Breast cancer of HER2 positive was relatively more characteristic than HER2 negative on imaging findings. |
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