| 武成聪 陈佳滨 蔡伟良 宁寅宽 李强.骨形态发生蛋白诱导骨髓间充质干细胞成骨分化的研究进展[J].,2014,14(21):4192-4195 |
| 骨形态发生蛋白诱导骨髓间充质干细胞成骨分化的研究进展 |
| The Research Status about Ossification of Bone Marrow StemCells underInduce of Bone Morphogenetic Protein |
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| DOI： |
| 中文关键词: 骨髓间充质干细胞 骨形态发生蛋白 骨化 骨生成 综述 |
| 英文关键词: Bone marrow mesenchymal cells Bone morphogenetic protein Ossification Bone formation Review |
| 基金项目:国家自然科学基金项目（31160199） |
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| 中文摘要: |
| 目前从骨髓中成功分离、鉴定BMSCs的方法较为成熟。新发现一些物质能诱导BMSCs向成骨细胞分化因子，其中对BMP
研究较多。其机制可能是通过结合Ⅰ、Ⅱ型BMP受体后激活Smad 信号通路诱导成骨。其诱导方法主要包括直接应用天然BMP
或者将BMP 及其协同基因转入BMSCs，通过靶细胞的持续表达BMP 促进新骨形成。本文将近10 年BMP诱导BMSCs 向成骨
分化的研究现状及发展趋势做一综述。 |
| 英文摘要: |
| The method of isolating and identification BMSCs from bone marrow has been commonly used. Some substances
have the function of promoting BMSCs differentiate to osteoblast, especially BMP. The mechanism may be activating Smad signaling
pathways through a combination of typeⅠandⅡ BMP receptor to induce osteogenesis. The main methods of inducing BMSCs to ossify
include direct application of natural protein BMP and transfer BMP genes with or without collaborative genes into BMSCs, and promoting
new bone formation by the continuous expression of BMP. In this report, we review the research status and development trends of using
BMP to promote BMSCs differentiate to osteoblasts in the recent 10 years. |
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