| 于丹 吴军凯 吴修红 都晓伟 王宏 孙慧峰.蜂花烧烫伤膏对烧伤大鼠血管内皮细胞的保护作用研究[J].,2014,14(21):4029-4032 |
| 蜂花烧烫伤膏对烧伤大鼠血管内皮细胞的保护作用研究 |
| Protective Effect of Fenghua Burning Wound Ointment on VascularEndothelial Cell of Severely Burned Rat |
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| DOI： |
| 中文关键词: 烧伤 肿瘤坏死因子alpha 内皮素 一氧化氮 ET-1/NO |
| 英文关键词: Fenghua Burning Wound Ointment TNF-alpha ET-1 NO ET-1/NO |
| 基金项目:黑龙江省自然科学基金项目（D201013） |
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| 中文摘要: |
| 目的：研究蜂花烧烫伤膏对烧伤大鼠血管内皮细胞的保护作用，探讨其治疗烧烫伤的作用机制。方法：热水烧伤法建立大鼠
30%TBSA 深Ⅱ度烧伤模型。造模成功后随机分为对照组、烧伤延迟复苏组、京万红组与蜂花烧烫伤膏组，分别立即给予相应干
预，并比较烫伤后1 h、3 h、6 h、12 h、24 h和48 h的肿瘤坏死因子-alpha（TNF-alpha）、内皮素（ET-1）、一氧化氮（NO）与ET-1/ NO 比值水
平。结果：与对照组大鼠比较，烧伤延迟复苏组TNF-alpha、ET-1 与ET-1/ NO 比值在伤后1 h即明显升高，12 h达高峰后逐渐下降；
NO的含量在伤后1h 即显著升高，6 h达高峰后逐渐下降；48h 后仍与对照组有较大差异。与烧伤延迟复苏组比较，蜂花烧烫伤膏
组各时相点的TNF-alpha、ET-1、NO 和ET-1/ NO比值均显著降低，但变化趋势基本一致。结论：蜂花烧烫伤膏通过降低TNF-alpha、ET-1
和NO水平，优化ET-1/NO系统，起到保护烧伤大鼠血管内皮细胞的作用。 |
| 英文摘要: |
| Objective:To investigate the effect of Fenghua Burning Wound Ointment on vascular endothelial cell (VEC) of
severely burned rat and attempt to explore its mechanisms.Methods:The 30% TBSA deep second degree burned models were
established by hot water. Then the models were randomized into normal control group, burned delayed fluid resuscitation group,
Jingwanhong group and Fenghua burining wound ointment group and each group was treated with drugs immediately. The levels of
TNF-alpha, ET-1, NO and ET-1/ NO were compared at 1, 3, 6, 12, 24, 48 h after rats were burned.Results:Compared with normal control
group, the level of TNF-alpha, ET-1 and ET-1/ NO increased significantly at 1h, reached the peak at 12 h and then decreased slowly in
burned delayed fluid resuscitation group. The level of NO increased significantly at 1h, reached the peak at 6h and then decreased slowly.
Compared with burned delayed fluid resuscitation group, the levels of TNF-alpha, ET-1, NO and ET-1/ NO decreased significantly, and the
variation tendency keep in accordance in Fenghua burning wound ointment group.Conclusion:Fenghua Burning Wound Ointment can
protect vascular endothelial cell of severely burned rat by reducing the levels of TNF-alpha, ET-1, NO and ET-1/NO. |
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