| 张伟王蓁△ 林伟王翔宇江金潇.子宫内膜癌组织中uPA 及Cath-D的表达及意义[J].,2014,14(20):3891-3895 |
| 子宫内膜癌组织中uPA 及Cath-D的表达及意义 |
| Expression and Clinical Significance of uPA and Cath-Din Endometrial Carcinoma |
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| DOI： |
| 中文关键词: 子宫内膜肿瘤 尿激酶型纤溶酶原激活剂 组织蛋白酶D 免疫组化 |
| 英文关键词: Endometrial neoplasms Urokinase-type plasminogen activator Cathepisn D Immunohistochemistry |
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| 中文摘要: |
| 摘要目的：检测子宫内膜癌组织中尿激酶型纤溶酶原激活物（uPA）及组织蛋白酶（Cath-D）的表达并探讨相关性及其临床意义。方
法：采用免疫组织化学方法（PV-6000 二步法）检测31 例子宫内膜癌组织（内膜癌组），17 例子宫内膜增生组织（增生组）及10 例
正常子宫内膜组织(对照组)中uPA 及Cath-D 的表达，并研究其相关性。结果：1.内膜癌组中uPA 和Cath-D的表达均高于增生组
及对照组中的表达，差异均有统计学意义（P<0.05)；在增生组中的表达与对照组差异无统计学意义（P>0.05）。2. uPA 和Cath-D 的
阳性表达与子宫内膜癌的临床病理分期、组织学分级及肌层浸润深度有关，差异均具有统计学意义（P<0.05）。3.内膜癌组中uPA
与Cath-D 的表达呈正相关（r=0.673，P<0.05）。结论：uPA 和Cath-D 在子宫内膜癌发生发展及侵袭转移过程中起着协同作用，
Cath-D 可诱导产生活化的uPA，促进癌细胞的浸润转移，因此，两者的联合检测可有助于成为判断子宫内膜癌的发展及预后的重
要指标。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the expression of urokinase-type plaminogen activator (uPA) and cathepsinD (Cath-D) in
endometrial carcinoma and the correlation of the expression with clinical pathological feature of endometrial carcinoma.Methods: Ten
cases of normal endometrium specimens, 17 cases was endometrium hyperplasia tissues, and 31 cases of endometrial cancer specimens,
were analyzed using immunohistochemistry. The relationships among uPA and Cath-D in the endometrial cancer were analyzed by X2
test, Fish's exactly test and Pearson test. Results:The positive expression rates of uPA and Cath-D in the endometrial carcinoma tissue
were significantly higher than those of the endometria1 hyperplasia tissue and the normal endometrial one's respectively(P<0.05). There's
no significance between the endometrial hyperplasia and the normal one's in the expression of uPA and Cath-D. The expression of uPA
and Cath-Dvaries according to the disease stage, histological grade and myometrial invasion of endometrial carcinoma (P<0.05). Cath-D
positive cases were significantly positively correlated with uPA positive cases (r=0.673, P<0.05).Conclusion: The interaction between
uPA and Cath-D plays a coordination role in the invasion and metastasis endometrial carcinoma. Cath-D can promote uPA in the process
of invasion and metastasis, so uPA and Cath-D may be important indexes to predict the prognosis of endometrial carcinoma. |
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