| 王晓倩1 史永华2△ 常珩3△ 塔拉甫·托坎2 美力班·吐尔逊2.表皮生长因子受体信号通路在维吾尔族妇女宫颈癌中
的表达研究*[J].,2014,14(20):3835-3839 |
| 表皮生长因子受体信号通路在维吾尔族妇女宫颈癌中
的表达研究* |
| Research on Expression of Epidermal Growth Factor ReceptorSignaling Pathway in Cervical Carcinoma in Uighur Women* |
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| DOI： |
| 中文关键词: EGFR ERK1/2 宫颈癌 |
| 英文关键词: EGFR ERK1/2 Cervical carcinoma |
| 基金项目:新疆维吾尔自治区自然科学基金面上项目（2012211A041） |
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| 中文摘要: |
| 摘要目的：随着表皮生长因子受体( epidermal growth factor receptor，EGFR)靶点治疗药物在其它肿瘤治疗中的应用，能否在妇科
肿瘤中应用并取得疗效，已经得到学者们的重视。但在临床应用之前，必须明确EGFR 与妇科肿瘤发生发展的关系及其机制。因
此，我们来探讨表皮生长因子受体EGFR 信号通路在维吾尔族不同级别宫颈病变组织中的差异表达及其临床意义。方法：应用免
疫组织化学方法检测EGFR、P-EGFR、ERK 1/2、P-ERK1/2 在108 例子宫颈癌，47 例CIN，79 例正常宫颈组织中的表达，并分析其
与临床病理参数的关系。结果：EGFR 在子宫颈癌、CIN 及正常宫颈组织中的阳性表达率分别是74.10%、66%、27.80%(P<0.01)；
P-EGFR 在三组间的阳性表达率分别是55.60%、74.50%、20.30% (P<0.01)；ERK1/2 在三组间的阳性表达率分别是60.10%、
76.60%、25.30%(P<0.01)；P-ERK1/2 在三组间的阳性表达率分别是44.40%、66%、24.10%(P<0.01)，其在宫颈癌中EGFR与与浸润
深度、淋巴结转移有关；ERK 与肿瘤的临床分期、远处转移有关，而且在宫颈癌中EGFR 与P-EGFR 、ERK 1/2、P-ERK1/2 的表达
成正相关(P<0.05)。结论：EGFR、P-EGFR 、ERK1/2、P-ERK1/2 的表达与宫颈癌的发生、发展相关，促进宫颈癌的浸润和转移，抑制
EGFR 信号通路可能为多靶点联合治疗宫颈癌提供新的方向。 |
| 英文摘要: |
| ABSTRACT Objective:With the application of epidermal growth factor receptor (EGFR) target therapy in various types of
oncotherapy, it has obtained much attention from scholars that whether it can be applied to gynecological tumors with certain curative
effects. But it is necessary to find out its relation with the occurrence of gynecologic cancer as well as the development of its mechanism.
Therefore, in this study we are to investigate different expressions and clinical significance of epidermal growth factor receptor (EGFR)
signal pathway in cervical lesions tissues of different grades in Uygur women. Methods:Immunohistochemistry is used to detect EGFR,
P-EGFR, ERK1/2,P-ERK1/2 in 108 cases of cervical cancer, 47 cases of CIN and 79 cases of normal cervical tissues and analyzes their
relationship with clinicopathological parameters.Results: EGFR expression rates in cervical cancer, CIN and normal cervical tissues were
74.10%, 66% and 27.80%(P<0.01), respectively; P-EGFR expression rates among the three groups were 55.60%, 74.50% and 20.30%
(P<0.01), respectively; ERK1/2 expression rates among the three groups were 60.10%, 76.60% and 25.30%(P<0.01), respectively;
P-ERK1/2 expression rates among the three groups were 44.40%, 66% and 24.10%(P<0.01), respectively. Their expressions in cervical
carcinoma were correlated with tumor invasion, lymphatic metastasis; ERK1/2 expressions were correlated with clinical stage, distant
metastasis; and EGFR and P-EGFR, ERK1/2, P-ERK1/2 in expression was positively correlated (P<0.05).Conclusion: Expressions of
EGFR, P-EGFR, ERK1/2 and P-ERK1/2 are correlated with occurrence and development in cervical cancer. Promoting cancer invasion
and metastasis, and inhibiting EGFR signaling pathway may provide a new direction to multi-target combination therapy of cervical
cancer. |
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