| 李云 吴再峰 张健 蒋淑婉 陈鹤.角质细胞生长因子(KGF)研究进展[J].,2014,14(19):3791-3793 |
| 角质细胞生长因子(KGF)研究进展 |
| Advances in Research for the Role of Keratinocyte Growth Factor |
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| DOI： |
| 中文关键词: 角质细胞生长因子 角质细胞生长因子受体 生物学功能 |
| 英文关键词: KGF KGFR Biological functions |
| 基金项目: |
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| 摘要点击次数: 826 |
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| 中文摘要: |
| 角质细胞生长因子(KGF) 属于成纤维细胞生长因子(FGFs)家族的成员之一，又称FGF 一7，最早由Rubin 等（1980）从人类
胎肺成纤维细胞培养液中分离提纯获得的。人KGF的cDNA编码一含194 个氨基酸的单链多肽，其分子量为26-28KD。KGF由
各种来源的间质细胞分泌，与肝素有较强的亲和力，其受体KGFR 属于蛋白酪氨酸激酶受体家族，目前已知该家族主要包括
FGFR1、FGFR2、FGFR3 和FGFR4 四位成员，KGFR 由FGFR2 基因编码，为FGFR-2 的剪接形式，即FGFR2Ⅲb，其主要分布于上
皮细胞，KGF与靶细胞膜上的受体KGFR 特异性结合后，促使受体自身磷酸化，从而启动细胞内信号级联反应，进而发挥多种生
物学功能：参与组织器官发育、促进细胞增殖及组织损伤修复、减少放化疗引起的副反应，尤其与癌症的发生发展有着密切的联
系。该文就KGF 的研究进展进行综述。 |
| 英文摘要: |
| Keratinocyte growth factor (KGF, fibroblast growth factor-7 (FGF-7) was first isolated from the conditioned medium
of the human embryonic lung fibroblast cell line, which was purified as a monomeric polypeptide with an apparent molecular mass of
26-28 kDa. KGF is a strong affinity for Heparin and mainly synthesized by mesenchymal cells. KGF receptor (KGFR), a member of the
tyrosine kinase receptors family including FGFR1, FGFR2, FGFR3 and FGFR4, is encoded by IIIb variants of the BEK/FGFR2 gene
(FGFR2b), which is expressed exclusively by various types of epithelial cells. it has been extensively proved that KGF exerts its
biological functions through binding to its specific receptor KGFR, including stimulating gcell proliferation, migration, and differentiation
in response to injury and tissue repair, especially also correlating with the development of the tumor. |
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