| 张真霞 张晖 王宝军 闫洁 庞江霞.睡眠呼吸暂停综合症与炎症反应及血管内皮调节相关性的研究进展[J].,2014,14(19):3779-3783 |
| 睡眠呼吸暂停综合症与炎症反应及血管内皮调节相关性的研究进展 |
| Review on the Association between Obstructive Sleep Apnea andInflammation Response and Vascular Regulation |
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| DOI： |
| 中文关键词: 睡眠呼吸暂停综合症 动脉粥样硬化 炎症因子 黏附分子 内皮素-1 |
| 英文关键词: Obstructive sleep apnea Atherosclerosi Inflammatory factor Adhesion molecules Endothelin-1 |
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| 中文摘要: |
| 阻塞性睡眠呼吸暂停综合征（Obstructive sleep apnea，OSA）是一种发病率高，具有一定潜在危险的全身性疾病，同时也是心
脑血管疾病的一个独立危险因素。其主要病理生理改变是睡眠过程中反复发生低氧和再氧合而引起的氧化应激反应，引发炎症
反应而导致心、脑血管为主的多系统损害。流行病学研究证据表明，一些循环水平的炎症因子在OSA 患者中升高, 与心脑血管疾
病发病风险相关。包括细胞粘附分子如粘附分子-1（intercellular adhesion molecule-1, ICAM-1）和选择素(selectins)，细胞因子如肿
瘤坏死因子alpha(TNF-a)和白细胞介素-6(interleukin-6,IL-6)，趋化因子如白细胞介素-8(interleukin 8,IL-8)和C-反应蛋白(C-reactive
protein)。此外，动脉粥样硬化是OSA 导致心脑血管疾病的重要的机制，OSA 后的炎症反应在动脉粥样硬化形成及发展的过程中
起着至关重要的作用，本文重点对OSA 后炎症因子启动及血管内皮调节的新近研究进行综述。 |
| 英文摘要: |
| Obstructive sleep apnea (OSA) is a highly prevalent and potential risk of systemic disease. Recent studies has
demonstrated OSA to be a major independent risk factor for cardio- or cerebrovascular diseases. The main pathophysiological progress in
OSA are occurring repeatedly hypoxia and reoxygenation during sleep resulting in reactive oxygen species (ROS), thereby initiating
inflammation which is associated with cardio- or cerebrovascular diseases. The epidemic studies have found that the circulating levels of
several markers of inflammation elevated in patients with OSA have been associated with cardiovascular incidence risk. These include
cell adhesion molecules such as intercellular adhesion molecule-1 and selectins, cytokines such as tumour necrosis factor alpha and
interleukin 6, chemokines such as interleukin 8, and C-reactive protein. Meanwhile, Atherosclerosis is the important mechanism. So
inflammatory processes in OSA play an important role in the pathogenesis of atherosclerosis. The present review focuses on possible
mechanisms that underlie inflammation activation and the regulation of vascular endothelial in OSA. |
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