| 黄慧 廖文军 粟钰淇 廖旺军 董烨.TGF-beta1、HIF-1alpha、VEGF在胃癌组织及癌旁组织中的表达及临床意义[J].,2014,14(18):3524-3527 |
| TGF-beta1、HIF-1alpha、VEGF在胃癌组织及癌旁组织中的表达及临床意义 |
| Expression and Clinical Significance of TGF-beta1, HIF-1alpha, VEGF in GastricCancer Tissues and Corresponding Adjacent Noncancerous Tissues |
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| DOI： |
| 中文关键词: 胃癌 TGF-beta1 HIF-1alpha VEGF |
| 英文关键词: Gastric cancer TGF-beta1 HIF-1alpha VEGF |
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| 中文摘要: |
| 目的：研究TGF-beta1（转化生长因子-beta1）、HIF-1alpha（低氧诱导因子-1alpha）、VEGF（血管内皮生长因子）在胃癌组织及癌旁组织中
的表达及临床意义。方法：选取于我院就诊的160 例胃癌手术患者切除的组织，采用免疫组化技术检测手术切除的胃癌组织中的
TGF-beta 1、HIF-1alpha及VEGF的表达，分析其与患者临床病理参数的关系。结果：免疫组化结果显示：TGF-beta1、HIF-1alpha及VEGF 在胃
癌组织中的表达均高于癌旁组织，差异均有统计学意义（P<0.05）；TGF-beta1、HIF-1alpha及VEGF 的表达均与肿瘤分期、淋巴结转移及
浸润深度有关（P<0.05）；VEGF的表达分别与TGF-beta1、HIF-1alpgha的表达呈相关关系（P<0.05）。结论：TGF-beta1、HIF-1alpha及VEGF在胃
癌组织中的表达与胃癌的病理学特征有关，检测TGF-beta1、HIF-1alpha及VEGF的表达将有助于临床诊治胃癌患者。 |
| 英文摘要: |
| Objective:To study the expression of TGF-beta1 (Transforming growth factor-beta1), HIF-1alpha(Hypoxia-inducible
factor-1alpha), VEGF(Vascular endothelial growth factor) and their clinical significance in gastric cancer tissues and corresponding adjacent
noncancerous tissues.Methods:160 cases of gastric carcinoma tissues were chosen to detect the expression of TGF-beta1, HIF-1alpha and
VEGF in gastric carcinoma tissues which had been removed by the immunohistochemistry technology. The relationship between the
expression and the clinical pathological parameters of patients were analyzed.Results:Immunohistochemistry showed: The expression of
TGF-beta1,HIF-1alpha, VEGF in gastric carcinoma tissues was higher than in corresponding adjacent noncancerous tissues, the differences
were all statistically significant (P<0.05); the expression of TGF-beta1, HIF-1alpha, VEGF was all related with neoplasm staging, lymphatic
metastasis and infiltration depth (P<0.05). The expression of VEGF were related with the expression of TGF-beta1 and HIF-1alpha(P<0.05).Conclusion:The expression of TGF-beta1, HIF-1alpha, VEGF in gastric carcinoma tissues were correlated with the pathological features of
gastric carcinoma, detecting the expression of TGF-beta1, HIF-1alpha, VEGF will be helpful to clinical diagnosis and treatment of patients with
gastric carcinoma. |
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