| 周婷1 贾素洁2 江俊麟1△.Eph-Ephrin 双向信号转导途径在眼部血管新生中的作用*[J].,2014,14(17):3365-3368 |
| Eph-Ephrin 双向信号转导途径在眼部血管新生中的作用* |
| Bidirectional Signaling Mechanismof Eph-Ephrinin Ocular Angiogenesis* |
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| DOI： |
| 中文关键词: Eph 受体 Ephrin 配体 血管新生 |
| 英文关键词: Eph receptor Ephrin ligand Angiogenesis |
| 基金项目:国家自然科学基金项目（81373408） |
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| 中文摘要: |
| 摘要：Eph/Ephrin 家族是受体酪氨酸激酶家族中的最大亚族,在生理和病理性血管形成中起重要作用。眼部血管生成是糖尿病视
网膜病、早产儿视网膜等眼部疾病致盲的重要因素，Eph 和Ephrin 基因在上述眼部疾病中有不同程度表达改变。Eph 受体及其配
体Ephrin 之间的双向信号机制是Eph-Ephrin 发挥功能的主要方式。本文就Eph-Ephrin 双向信号机制在眼部血管新生中的作用
进行综述。 |
| 英文摘要: |
| ABSTRACT:Eph/Ephrin, the largest subfamily of receptor tyrosine kinases (RTKs), plays an important role in both physiological
and pathological angiogenesis. Ocular angiogenesis is an important pathological phenomenon of some ocular disorders such as diabetic
retinopathy and retinopathy of prematurity, which may result in blindness. It has been reported that there are alteration of Eph and Ephrin
expression in ocular angiogenesis-related disorders, suggesting that Eph-Ephrin maybe play roles in ocular angiogenesis. Eph-Ephrin
exerts their roles by the bidirectional signaling between Eph receptor and Ephrin ligand. This review focused on the roles of bidirectional
signaling of Eph-Ephrin in ocular angiogenesis. |
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