| 王鑫 周平 李东琼 李远 赵大愚.他克莫司和卡泊三醇软膏治疗四肢斑块状银屑病的疗效和安全性分析[J].,2014,14(16):3084-3086 |
| 他克莫司和卡泊三醇软膏治疗四肢斑块状银屑病的疗效和安全性分析 |
| The Efficacy and Safety Analysis of Tacrolimus and Calcipotriol Ointment inthe Treatment of Limbs Plaque Psoriasis |
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| DOI： |
| 中文关键词: 他克莫司 卡泊三醇软膏 四肢斑块状银屑病 |
| 英文关键词: Tacrolimus Calcipotriene ointment Limbs plaque psoriasis |
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| 中文摘要: |
| 目的：探讨他克莫司和卡泊三醇软膏治疗四肢斑块状银屑病的疗效和安全性。方法：选取2011 年4 月至2013 年8 月于我
院诊治的84 例四肢斑块状银屑病患者，将患者随机分为A 组和B 组，每组各42例，分别采用他克莫司和卡泊三醇软膏治疗。评
定PASI以及疗效指数，并对用药过程中患者的不良事件进行观察记录。结果：A、B 两组患者治疗后各时间点PASI评分与治疗前
相比较均显著降低，差异有统计学意义（P＜0.05）；但同一时间组间对比，差异并无统计学意义（P＞0.05）。A 组银屑病患者的总有
效率为64.29%，与B 组的69.05%相比，差异无统计学意义（P＞0.05）。结论：他克莫司与卡泊三醇软膏治疗四肢斑块状银屑病均
安全有效，且二药相比，疗效相当。 |
| 英文摘要: |
| Objective: To investigate the efficacy and safety of tacrolimus and calcipotriol ointment in the treatment of limbs
plaque psoriasis.Methods:84 cases of patients with limbs plaque psoriasis from April 2011 to August 2013 in our hospital were selected
and randomly divided into group A and group B. 42 cases were in each group and were given tacrolimus and calcipotriol ointment
treatment respectively. The efficacy index PASI assessment and adverse events of treatment during the observation were recorded.Results:The PASI scores of the two groups at each time point after treatment were significantly lower than before treatment, the
difference was statistically significant (P<0.05). But there was no differnce between the two groups at the same time point(P> 0.05). The
total effective rate of Group A (64.29%) also showed no statistically significant difference compared with that of group B (69.05%)
(P>0.05).Conclusion:Tacrolimus and calcipotriol ointment are safe and effective in healing limbs plaque psoriasis , and there is no
significant difference in efficacy between the two drugs. |
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