| 刘焕焕 李建英 于俊生 黄克基 吕洪.柴半六合汤对慢性肾衰竭模型大鼠血清胃泌素、胃动素
及生长抑素的影响[J].,2014,14(16):3051-3055 |
| 柴半六合汤对慢性肾衰竭模型大鼠血清胃泌素、胃动素
及生长抑素的影响 |
| The Effect of Chaibanliuhe decoction on GAS，MTL and SS in Rat Modelswith Chronic Renal Failure |
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| DOI： |
| 中文关键词: 柴半六合汤 肾衰竭大鼠 胃动素 胃泌素 生长抑素 |
| 英文关键词: Chaibanliuhe decoction CRF rats GAS MTL SS |
| 基金项目:青岛市2010 年度中医科研计划项目（2009-zyy007） |
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| 中文摘要: |
| 目的:观察柴半六合汤对慢性肾衰竭（CRF）模型大鼠血清胃泌素(GAS)、胃动素(MTL)、生长抑素(SS)水平的影响，探讨其作
用机制。方法: 采用5/6 肾切除的方法复制CRF大鼠模型，设立假手术组、模型组、柴半六合汤高剂量组、低剂量组、尿毒清对照
组，检测血肌酐（Scr）、尿素氮（BUN）、胃泌素(GAS)、胃动素(MTL)及生长抑素(SS)，取胃粘膜行HE 染色，光镜下观察其组织病理
变化。结果: 用药各组大鼠治疗后Scr、BUN 低于模型组；柴半六合汤高剂量组大鼠Scr 、BUN、GAS、MTL 低于低剂量组、SS高于
低剂量组；柴半六合汤高、低剂量组大鼠GAS、MTL低于尿毒清对照组、SS 高于尿毒清对照组。结论: 柴半六合汤通过降低CRF
模型大鼠GAS、MTL水平、SS 升高水平，改善胃肠道症状。 |
| 英文摘要: |
| Objective: To observe the effect of Chaibanliuhe decoction on the levels of Gastric secrete element(GAS), Gastric dynamic
element(MTL), somatostatin(SS) in rat chronic renal failure(CRF) model, and to explore its mechanism.Methods:The model of
CRF in rats were established by the method of 5/6 nephrectomy. Rats were randomly divided into control group, model control group,
high Chaibanliuhe decoction group, low Chaibanliuhe decoction group and Niaoduqing control group. The levels of Scr, BUN, GAS,
MTL and SS in serumwere detected, and the pathological changes of Gastric mucosa were observed by hematoxylin-eosin (HE) staining.Results:Compared with model control group, Scr, BUN, GAS and MTL decreased while SS increased significantly in every administration
group. The levels of Scr, BUN, GAS and MTLin the high Chaibanliuhe decoction group were lower than that in the low Chaibanliuhe
decoction group and Niaoduqing control group while the level of SS was higher. Compared with that in the Niaoduqing control group,
GAS and MTL decreased while SS increased in the low Chaibanliuhe decoction group. There was no significant difference between low
Chaibanliuhe decoction group and Niaoduqing control group with the levels of Scr and BUN.Conclusion:Chaibanliuhe decoction can
improve the gastrointestinal symptoms of CRF in rat model by decreasing the levels of GAS and MTL and increasing the level of SS. |
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