| 关婷胡瑞成△ 戴爱国.PRDM 基因与非小细胞肺癌关系的研究现状*[J].,2014,14(15):2997-3000 |
| PRDM 基因与非小细胞肺癌关系的研究现状* |
| Research Status on the correlation of PRDMGenes with Non-smallCell Lung Cancer* |
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| DOI： |
| 中文关键词: PRDM基因 肺肿瘤 DNA甲基化 抑癌基因 |
| 英文关键词: PRDMgenes Lung neoplasms DNA methylation Tumor suppressor gene |
| 基金项目:国家自然科学基金项目（81070035） |
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| 中文摘要: |
| 摘要：肺癌是当今世界上严重威胁人类健康的恶性肿瘤，具有高发病率和高死亡率。目前缺乏理想的早期诊断手段。PRDM基因
家族是近年来新发现的与人类肿瘤形成相关的转录调节因子家族，通过启动子区高甲基化参与多种肿瘤形成，并在细胞分化和
恶变中发挥重要作用。目前，对于PRDM基因在非小细胞肺癌中作用的研究多集中在PRDM1、PRDM5 和PRDM14。本文主要综
述了PRDM1、PRDM5 和PRDM14 在非小细胞肺癌中的表达及其与非小细胞肺癌患者临床特征关系的研究现状。PRDM基因有
望成为肺癌的早期诊断和预后评估的新靶点。 |
| 英文摘要: |
| ABSTRACT:Lung cancer is a kind of malignant tumor with high morbidity and mortality which seriously threaten human's health
in the world nowadays.No ideal early diagnostic method has been found. PRDMgenes is a newly discovered transcription factors family
related to the tumorigenesis, which is overexpressed in various tumors and involved in the formation of various tumors, cell differentiation
and malignant transformation through the methylation of promoter in these genes. Currently, the researches about PRDM genes in
non-small cell lung cancer are focused on PRDM1, PRDM5 and PRDM14. This article mainly review the expression of these genes in
non-small cell lung cancer and their relationship with the clinic features of patients with non-small cell lung cancer.PRDMgenes could be
used as a new target for the early diagnosis and prognosis evaluation of non-small cell lung cancer. |
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