| 何丽1 黄长形1△ 李江斌2 申焕君1 胡萍1 朱婷1.LAG-3 分子的研究进展*[J].,2014,14(15):2989-2993 |
| LAG-3 分子的研究进展* |
| The Research Progress of LAG-3 Molecular* |
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| DOI： |
| 中文关键词: LAG-3 Tr细胞 糖尿病 肿瘤 病毒感染 |
| 英文关键词: LAG-3 Tr cell Diabetes Tumor Virus infection |
| 基金项目:国家自然科学基金项目（81072434） |
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| 中文摘要: |
| 摘要：淋巴细胞活化基因-3（lymphocyte activation gene-3,LAG-3,CD223）是免疫球蛋白超家族的成员之一，是对淋巴细胞具有抑
制作用的分子。LAG-3定位于人12 号染色体，与CD4 具有密切关系。研究发现猪LAG-3 分子的结构和表达模式在哺乳动物物种
中是共有的，并且可溶性的猪LAG-3 对控制人-猪异种T 细胞免疫反应有作用。LAG-3 分子主要表达于活化的NK 细胞、T 淋巴
细胞表面，与HLA-II高亲和力结合。Tr 细胞是具有调节调节功能的T 细胞亚群，发现Tr 细胞表面标志CD49b 和LAG-3可在人
和小鼠Tr1 细胞表面表达。CD49b 和LAG-3 的发现，使得在体内对Tr细胞进行跟踪具有可行性，纯化Tr1 细胞作为一种细胞治
疗方法具有可行性。LAG-3通过对胰腺中抗原特异性T 细胞增殖的选择性抑制，可以使用LAG-3 作为1型糖尿病病情进展的一
种新的替代标记，检测LAG-3 分子可能成为T细胞定向免疫治疗效果评估的一种方法。肿瘤浸润的CD8+T细胞表面LAG-3 表
达上调，LAG-3 的抑制作用在HCC的细胞免疫应答中发挥着重要的作用，可见阻断LAG-3 分子的表达有可能成为治疗肿瘤的
新方法。慢性病毒感染性疾病时常常发生T 细胞衰竭，T细胞通过LAG-3 分子的限制作用和MHCⅡ类信号分子的表达其抑制功
能，这有利于慢性病毒感染性疾病的治疗。疟原虫感染增加了抑制性受体LAG-3 的表达，疟原虫感染引起的特异性T细胞功能
衰竭可通过抑制性疗法来治疗。LAG-3 的表达可能有利于黑色素瘤的增殖，阻断LAG-3-MHCⅡ类分子相互作用的化合物可用于
黑色素瘤的治疗。此外，使用LAG-3 毒性抗体选择性的靶向激活T 细胞可阻碍T 细胞参与的迟发型超敏反应。 |
| 英文摘要: |
| ABSTRACT:Lymphocyte activation gene -3 (lymphocyte activation gene-3, LAG-3, CD223) is one of immunoglobulin superfamily
numbers. It is a inhibitory molecule for lymphocytes. LAG-3 is located on human chromosome 12, a close relationship with CD4.Study
found that pig LAG-3 molecule structure and expression patterns in mammalian species are common. Soluble pig LAG-3 play a role in
person - Pig heterologous T cell immune responses. LAG-3 molecule is mainly expressed on activated NK cells, T lymphoctes. It has
high affinity with HLA-II. Tr cells are capable of regulating the regulatory function of T cell subsets and found Tr cell surface markers
CD49b and LAG-3 in human and mouse Tr1 cell.CD49b and LAG-3 is found, which make purified Tr1 cells as a cell therapy approach
become feasible LAG-3 could inhibit selectively antigen-specific T cells in the pancreas. As a result, LAG-3 can be used as a new surrogate
marker in the progression of type 1 diabetes. Detecting LAG-3 molecules may be a new method in directed T cell immunotherapy
effect assessment. Tumor infiltrating CD8+ T cells up-regulated LAG-3. LAG-3 plays an important role in HCC. Blocking the expression
of LAG-3 molecule may become a new method of cancer treatment. Chronic viral infection often occurs when T cells failure. T cells
play its suppression function via the limitations of LAG-3 molecule and MHCⅡ, which is conducive to chronic viral infectious diseases.
Plasmodium infection increases the expression of LAG-3, and it could be treated by inhibiting therapy. LAG-3 expression may favor the
proliferation of melanoma, and blocking LAG-3-MHCⅡ molecules interacting compounds can be used in the treatment of melanoma. In
addition, the use of LAG-3 antibodies selective toxicity of T cell activation can hinder targeting T cells which were involved in delayed-
type hypersensitivity. |
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