| 谢念林曹祥△ 严四军邓波荣徐绍敢.低分子肝素雾化吸入对急性肺损伤治疗作用的实验研究[J].,2014,14(15):2867-2870 |
| 低分子肝素雾化吸入对急性肺损伤治疗作用的实验研究 |
| Therapeutic Effects of Low Molecular Weight Heparin Nebulizationon Acute Lung Injury |
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| DOI： |
| 中文关键词: 低分子肝素 雾化治疗 急性肺损伤 |
| 英文关键词: Low molecular weight heparin Nebulization therapy Acute lung injury |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：急性肺损伤死亡率高且目前尚无有效可靠的治疗方法，本研究旨在探讨低分子肝素雾化吸入对急性肺损伤的治疗作
用。方法：健康纯种白兔24 只，随机分成3 组(n=8)：① 正常对照组，② 生理盐水雾化组，③ 低分子肝素雾化治疗组。各组分别测
定动脉血气、肺干/湿重比、支气管肺泡灌洗液总蛋白含量和凝血功能。结果：与正常对照组相比，生理盐水雾化组和低分子肝素
雾化治疗组动脉血氧合指数、肺干/ 湿重比值显著降低(P<0.05)，支气管肺泡灌洗液总蛋白含量显著升高(P<0.05)，而低分子肝素
雾化治疗组较生理盐水雾化组动脉血氧合指数、肺干/ 湿重比值显著升高(P<0.05)，支气管肺泡灌洗液总蛋白含量显著降低(P<
0.05)；凝血酶原时间以及活化部分凝血活酶时间生理盐水雾化组和低分子肝素雾化治疗组间没有显著差异(P>0.05)，但均较正常
对照组延长(P<0.05)。结论：低分子肝素雾化吸入治疗可以改善肺换气，提高氧合，降低肺泡渗出，并且对凝血功能没有明显的副
作用，可以在一定程度上缓解急性肺损伤。本研究为急性肺损伤的治疗提供了新的思路和实验依据。
关键词：低分子肝素；雾化治疗；急性肺损伤
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| 英文摘要: |
| ABSTRACT Objective:As high mortality and lack of effective treatment of acute lung injury, the purpose of this study is to explore
the therapeutic effects of low molecular weight heparin nebulization on acute lung injury. Methods:Twenty-four rabbits were randomly
divided into three groups (n=8)：control group, saline nebulization group and low molecular weight heparin nebulization group. Arterial
blood gas, ratio of dry/wet lung, content of total protein in bronchoalveolar lavage fluid (BALF) and blood coagulation were monitored in
three groups respectively. Results：Compared with control group, oxygenation index and ratio of dry/wet lung in both saline nebulization
group and low molecular weight heparin nebulization group decreased significantly (P<0.05). Content of total protein in BALF increased
significantly (P<0.05). While oxygenation index and ratio of dry/wet lung in low molecular weight heparin nebulization group increased
significantly (P<0.05), content of total protein in BALF decreased significantly (P<0.05) compared with saline nebulization group. There
was no significant difference(P>0.05) in prothrombin time (PT) and activated partial thromboplastin time (APTT) between saline nebulization
group and low molecular weight heparin nebulization group although both of them increased significantly (P<0.05) compare with
control group. Conclusion：Low molecular weight heparin nebulization may improve pulmonary gas exchange, increase oxygenation index
and decrease alveolar exudation without apparent adverse effects, and therefore attenuate acute lung injury to some extent. This study
provided new idea and experimental data for treatment of acute lung injury. |
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