| 尹肖云 乔丽雅 王红英 张秦 杨夕粉 王振国.PTEN基因和P53基因在子宫内膜癌中的表达及意义[J].,2014,14(14):2628-2631 |
| PTEN基因和P53基因在子宫内膜癌中的表达及意义 |
| Expression and Clinical Significance of PTEN Gene and P53 Genein Endometrial Carcinoma |
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| DOI： |
| 中文关键词: PTEN P53 子宫内膜癌 |
| 英文关键词: PTEN P53 Endometrial carcinoma |
| 基金项目:国家自然科学基金项目（30872749) |
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| 中文摘要: |
| 目的：探讨PTEN 基因和P53 基因在子宫内膜癌中的表达及临床意义,为子宫内膜癌的治疗提供参考依据。方法：用免疫组
化法检测50 例子宫内膜癌患者PTEN基因缺失和P53 基因突变情况，并分析两者与子宫内膜癌不同病理变化的相关性。结果：
PTEN 缺失24 例，缺失率48.00%，进一步研究显示PTEN缺失与细胞分化程度和肌层浸润情况密切相关（P＜0.05），P53 突变32
例，缺失率64.00%，并进一步研究显示P53 突变与FIGO 分期，细胞分化程度和肌层浸润情况密切相关（P＜0.05）。结论：PTEN 基
因缺失和P53 基因突变与子宫内膜癌发生和发展密切相关，以PTEN 基因和P53 基因为靶点的生物治疗在进展期内膜癌中的治
疗价值值得进一步深入研究。 |
| 英文摘要: |
| Objective:To study the effect of deletion of PTENGene and mutation of P53 gene on endometrial carcinoma, provides
the reference for the treatment of uterine endometrial carcinoma.Methods:Immunohistochemistry was used to deletion of PTEN Gene
and mutation of P53 gene, and analyze both with endometrial cancer pathology.Results:Deletion of PTEN Gene in 24 cases, the loss rate
of 48%Further study showed that the expression of deletion of PTEN gene significantly correlated with cell differentiation and
myometrial invasion (P<0.05), mutation of P53 gene the mutation being64.00%, and Further study showed that the mutation of P53 gene
significantly correlated with FIGO stage, cell differentiation and myometrial invasion situation (P<0.05).Conclusion:Deletion of PTEN
gene and mutation of P53 gene, was associated with endometrial carcinoma development. The PTEN gene and P53 gene as the
therapeutic value of target of biological treatment in the progression of endometrial carcinoma is worthy of further study. |
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